Alkaline ceramidase 2 (Acer2)

Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated quite long-chain ceramides and short-chain ceramides were poor substrates.

Inhibits the maturation of protein glycosylation in the Golgi complex, such as that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by decreasing the degree of ITGB1 in the cell surface.