2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (ACMSD)

Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) into alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically into quinolate (QA), a key precursor of NAD, and a powerful endogenous excitotoxin of neuronal cells that's implicated in the pathogenesis of various neurodegenerative disorders.

In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.