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- Table of Contents
Facts about 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase.
In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
Human | |
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Gene Name: | ACMSD |
Uniprot: | Q8TDX5 |
Entrez: | 130013 |
Belongs to: |
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metallo-dependent hydrolases superfamily |
aminocarboxymuconate semialdehyde decarboxylase; EC 4.1.1.45,2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Picolinate carboxylase
Mass (kDA):
38.035 kDA
Human | |
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Location: | 2q21.3 |
Sequence: | 2; NC_000002.12 (134838319..134902906) |
PMID: 12140278 by Fukuoka S., et al. Identification and expression of a cDNA encoding human alpha-amino- beta-carboxymuconate-epsilon-semialdehyde decarboxylase (ACMSD). A key enzyme for the tryptophan-niacine pathway and 'quinolinate hypothesis'.
PMID: 19843166 by Garavaglia S., et al. The crystal structure of human alpha-amino-beta-carboxymuconate- epsilon-semialdehyde decarboxylase in complex with 1,3- dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis.