Acyl-coenzyme A synthetase ACSM1, mitochondrial (ACSM1)

Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro).

Functions as GTP-dependent lipoate- activating enzyme which generates the substrate for lipoyltransferase (By similarity). .