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- Table of Contents
1 Citations
Facts about Disintegrin and metalloproteinase domain-containing protein 9.
Cleaves and releases a number of molecules with Significant roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5.
May mediate cell-cell, cell- matrix interactions and regulate the motility of cells via interactions with integrins..
| Human | |
|---|---|
| Gene Name: | ADAM9 |
| Uniprot: | Q13443 |
| Entrez: | 8754 |

| Belongs to: |
|---|
| No superfamily |

a disintegrin and metalloproteinase domain 9 (meltrin gamma); ADAM 9; ADAM metallopeptidase domain 9 (meltrin gamma); ADAM metallopeptidase domain 9; ADAM9; Cellular disintegrin-related protein; cone rod dystrophy 9; CORD9; disintegrin and metalloproteinase domain-containing protein 9; EC 3.4.24; EC 3.4.24.-; MCMP; MCMPMDC9KIAA0021Mltng; MDC9; Meltrin gamma; Meltrin-gamma; Metalloprotease/disintegrin/cysteine-rich protein 9; MLTNG; Myeloma cell metalloproteinase
Mass (kDA):
90.556 kDA

| Human | |
|---|---|
| Location: | 8p11.22 |
| Sequence: | 8; NC_000008.11 (38996767..39105261) |
Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart.
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.





PMID: 8647900 by Weskamp G., et al. MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains.
PMID: 8809033 by McKie N., et al. Cloning of a novel membrane-linked metalloproteinase from human myeloma cells.