ADAMTS2 Antibodies

AND ADAMTS2 ELISA kits, ADAMTS2 Proteins

Many biological assays use antibodies to detect ADAMTS2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ADAMTS2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ADAMTS2 antibodies...

We validate the specificity of these antibodies to ADAMTS2 by testing them on tissues known to express ADAMTS2 positively and negatively. Browse below to find the ADAMTS2 antibody that suites your experiment. We have 0 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: CCN4 Next: FXR2

ADAMTS2 Infographic by Boster Bio

All ADAMTS2 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

ADAMTS2 Overview

Facts about A disintegrin and metalloproteinase with thrombospondin motifs 2.

ADAMTS2 3D structure. Source: alphafold

A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAMTS2)

Cleaves the propeptides of type I and II collagen before fibril assembly. Does not act on type III collagen.

May also play a role in growth that is independent of its role in collagen biosynthesis. .

Gene Information

Human
Gene Name:	ADAMTS2
Uniprot:	O95450
Entrez:	9509

Family

Belongs to:

No superfamily

Alternative Names

A disintegrin and metalloproteinase with thrombospondin motifs 2; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 2; ADAM metallopeptidase with thrombospondin type 1 motif, 2; ADAM-TS 2; ADAMTS-2; ADAM-TS2EC 3.4.24.14; ADAMTS-3; EC 3.4.24; NPIDKFZp686F12218; PC I-NP; PCI-NP; PCINPhPCPNI; PCPNI; PNPI; Procollagen I N-proteinase; Procollagen I/II amino propeptide-processing enzyme; Procollagen N-endopeptidase

Molecular Weight

Mass (kDA):
134.755 kDA

Genomic Context


Human

Location:	5q35.3
Sequence:	5; NC_000005.10 (179110853..179345461, complement)

Tissue Specificity

Expressed at high level in skin, bone, tendon and aorta and at low levels in thymus and brain.

Subcellular Localizations

Secreted, extracellular space, extracellular matrix.

Diseases

Ehlers-danlos Syndrome
Tumor Angiogenesis
Malignant Neoplasms
Ehlers-danlos Syndrome, Dermatosparaxis Type
Neoplasms
Degenerative Polyarthritis
Collagen Diseases
Carcinoma
Dysplasia
Thrombocytopenic Purpura
Hereditary Diseases
Malignant Paraganglionic Neoplasm
Connective Tissue Diseases

Purpura, Thrombotic Thrombocytopenic
Fracture
Tissue Adhesions
Premature Birth
Purpura
Neoplasm Metastasis
Adenoma

Pathways

Angiogenesis
Coagulation
Cell Migration
Immune Response
Proteolysis
Cell-matrix Adhesion
Muscle Contraction
Embryo Development
Reverse Transcription
Dentinogenesis

Cell Cycle
Pathogenesis
Tissue Homeostasis
Secretion

PTMs

Cleavage

Research Areas

Angiogenesis
Cancer
Extracellular Matrix

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ADAMTS2

References

PMID: 10417273 by Colige A., et al. Human Ehlers-Danlos syndrome type VII C and bovine dermatosparaxis are caused by mutations in the procollagen I N-proteinase gene.

PMID: 31152061 by Rosell-Garcia T., et al. Differential cleavage of lysyl oxidase by the metalloproteinases BMP1 and ADAMTS2/14 regulates collagen binding through a tyrosine sulfate domain.