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- Table of Contents
Facts about A disintegrin and metalloproteinase with thrombospondin motifs 2.
May also play a role in growth that is independent of its role in collagen biosynthesis. .
Human | |
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Gene Name: | ADAMTS2 |
Uniprot: | O95450 |
Entrez: | 9509 |
Belongs to: |
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No superfamily |
A disintegrin and metalloproteinase with thrombospondin motifs 2; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 2; ADAM metallopeptidase with thrombospondin type 1 motif, 2; ADAM-TS 2; ADAMTS-2; ADAM-TS2EC 3.4.24.14; ADAMTS-3; EC 3.4.24; NPIDKFZp686F12218; PC I-NP; PCI-NP; PCINPhPCPNI; PCPNI; PNPI; Procollagen I N-proteinase; Procollagen I/II amino propeptide-processing enzyme; Procollagen N-endopeptidase
Mass (kDA):
134.755 kDA
Human | |
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Location: | 5q35.3 |
Sequence: | 5; NC_000005.10 (179110853..179345461, complement) |
Expressed at high level in skin, bone, tendon and aorta and at low levels in thymus and brain.
Secreted, extracellular space, extracellular matrix.
This is the place to be if you are unsure if Steven Boster's ADAMTS2 marker is the right one for you. This guide will explain the features of the ADAMTS2Marker as well as its high-affinity primary antibodies , as well as gene infographics. We'll also provide some tips for optimizing your experiments. If you follow these tips will increase the effectiveness of your experiments effective and make the most of your Boster Bio system.
Human RXFP1 protein's ADAMTS2 marker has an exceptionally high conservation rate. Antibodies against this protein need to recognize distinct epitopes of peptides. Therefore, antibodies that are raised against ADAMTS2 are likely to not recognize the same epitopes as the immunogen. Researchers who wish to confirm the specificity and effectiveness of the antibodies have to deal with this problem.
The ADAMTS2 marker is a well acknowledged epitope for a variety of biological targets. The ADAMTS2 marker has been used by Boster to develop high-affinity primary antibodies that recognize the ADAMTS2 marker. These antibodies can also function as sandwich ELISAs. This is a popular method in clinical settings. Research studies where the presence of a specific analyte in a basic preparation are particularly well-served by the ADAMTS2 marker.
The antibodies used in immunocytochemistry must bind a specific antigen with high affinity, and permit long incubations without background staining. The high concentration of primary antibodies is essential for avoiding non-specific interactions with target antigen. Signal attenuation is also caused by short incubations. It is essential to choose an antigen specific primary antibody.
Monoclonal antibodies on the other side are cheaper and more robust. They recognize multiple epitopes in an antigen and are more resistant to thorough washing. Researchers can ask more questions about the specimens. This provides more reliable results and better context-based data. Because monoclonal antibody are specifically designed to be dual label they are more specific than polyclonal antibody.
High affinity is desirable , but it can make it difficult to differentiate the antibody from its antigen. The antibody must be removed by extreme methods if it can not break off. These methods may be necessary if the antibody is to be effective in immunohistochemistry. The ADAMTS2 marker is utilized to differentiate monoclonal from polyclonal antibody.
While mIHC is based on the chromogenic mIHC Boster's high-affinity antibodies use the ADAMTS2 marker. They recognize the ADAMTS2 epitope that has a high affinity, a low background and low cross-reactivity. And, because monoclonal antibodies have the highest homogeneity, they are highly specific.
If you've ever wondered the process of passing genes from one generation to the next, you've likely seen Boster's gene infographics. These visual representations of mouse and human genomes offer basic details about each gene. If you don't know the exact gene you're looking for then search the database to find it. The informational graphics are a great way to understand the genes that are in your family. They could even inspire you to conduct your own research.
PMID: 10417273 by Colige A., et al. Human Ehlers-Danlos syndrome type VII C and bovine dermatosparaxis are caused by mutations in the procollagen I N-proteinase gene.
PMID: 31152061 by Rosell-Garcia T., et al. Differential cleavage of lysyl oxidase by the metalloproteinases BMP1 and ADAMTS2/14 regulates collagen binding through a tyrosine sulfate domain.