This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about A-kinase anchor protein 2.
. .
Rat | |
---|---|
Gene Name: | Akap2 |
Uniprot: | Q5U301 |
Entrez: | 298024 |
Belongs to: |
---|
No superfamily |
A kinase (PRKA) anchor protein 2; AKAP-2; FLJ53197; protein kinase A2
Mass (kDA):
95.941 kDA
Rat | |
---|---|
Location: | 5q24 |
Sequence: | 5; |
Look no further if your goal is to find an antibody that detects AKAP2. Boster has high-affinity primary antibodies that have been extensively cited in the literature over the past 25 years. Additionally, they've been validated on Western Blotting, Immunohistochemistry, and ELISA. They are the best choice in your next research project.
AKAP2 is a versatile biomarker with many applications. It can be used in research to determine the effects on the human endocrinology system of drugs. AKAP is a blocker of cyclooxygenase-2 (COX2) 2 activity. It has been shown to inhibit COX-2 activity and can be used as a drug target.
AKAPs bind dimeric A subunits. 23 amino-terminal residues form the hydrophobic layer. The AD region of human RIIa binds with this hydrophobic area. This hydrophobic area is also known by the AKAP binding region. The AKAP binding domain is located within the same 44 amino acid sequence as AD. This region is responsible to binding AKAPs and is highly conserved.
AKAP2-associated Proteins (AKAPs), play a critical role in the regulation of phosphorylation for Akt, and PI3K. The AKAP2 gene is expressed in many tissues including the brain, eyes, and gastrointestinal tract. In addition to expressing the gene in various tissues, AKAP2 is also present in cancer cells. In this study, the AKAP2 protein was detected in three human tumor tissues.
AKAPs bind to dimeric R subunits. 23 amino-terminal residues form a hydrophobic surface that binds the AD of human RIIa. This is the AKAP-binding domain. This region is located within the AKAP binding site's 44 amino acid sequence. Alto et al. first identified the AKAP2 gene. in 1984.
The AKAP2 peptide marker is a versatile peptide. It is highly versatile, allowing researchers to target it in different applications. The AKAP protein is found in many tissues such as the brain, heart, lungs, and stomach. The gene can therefore be targeted for therapeutic intervention. A tumor-suppressor protein may be added to a patient suffering from lung cancer. A high percentage of patients with cancer express the AKAP2 gene in their brains.
PMID: 16641100 by Hoffert J.D., et al. Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites.
PMID: 22673903 by Lundby A., et al. Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.