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AKR1A1 Antibodies
AND AKR1A1 ELISA kits, AKR1A1 Proteins
Many biological assays use antibodies to detect AKR1A1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with AKR1A1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop AKR1A1 antibodies...
Designing an IHC experiment for AKR1A1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the AKR1A1 IHC GuideAKR1A1 Infographic by Boster Bio
All AKR1A1 Products
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AKR1A1 Overview
Facts about Aldo-keto reductase family 1 member A1.
Aldo-keto reductase family 1 member A1 (AKR1A1)
Catalyzes the NADPH-dependent reduction of many different aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol.
Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid.
Gene Information
| Human | |
|---|---|
| Gene Name: | AKR1A1 |
| Uniprot: | P14550 |
| Entrez: | 10327 |
Family
| Belongs to: |
|---|
| aldo/keto reductase family |
Alternative Names
alcohol dehydrogenase [NADP+]; alcohol dehydrogenase; Aldehyde reductase; Aldo-keto reductase family 1 member A1; aldo-keto reductase family 1, member A1 (aldehyde reductase); ALDR1; ALRMGC1380; ARM; DD3; dihydrodiol dehydrogenase 3; EC 1.1.1; EC 1.1.1.2; MGC12529
Molecular Weight
Mass (kDA):
36.573 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p34.1 |
| Sequence: | 1; NC_000001.11 (45550779..45570051) |
Tissue Specificity
Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung.
Subcellular Localizations
Cytoplasm, cytosol. Apical cell membrane.
Diseases
- Malignant Neoplasms
- Carcinoma
- Cardiotoxicity
- Lymphoma
- Adenocarcinoma
- Lymphoma, Non-hodgkin
- Neoplasms
- Liver Carcinoma
- Diffuse Large B-cell Lymphoma
- Adenocarcinoma Of Lung (disorder)
- Malignant Neoplasm Of Lung
- Lung Neoplasms
- B-cell Lymphomas
Interacting Proteins
- TERF2IP
Pathways
- Cell Proliferation
- Drug Resistance
- Transport
- Dna Repair
- Respiratory Burst
- Cell Cycle Arrest
- Response To Oxidative Stress
- Flight
- Cell Cycle
PTMs
- Oxidation
- Phosphorylation
Research Areas
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AKR1A1
bosterbio.com/bosterbio-gene-info-cards/AKR1A1
References
PMID: 2498333 by Bohren K.M., et al. The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases.
PMID: 10393438 by Fujii J., et al. The structural organization of the human aldehyde reductase gene, AKR1A1, and mapping to chromosome 1p33-->p32.