This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Aldo-keto reductase family 1 member A1.
Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid.
Human | |
---|---|
Gene Name: | AKR1A1 |
Uniprot: | P14550 |
Entrez: | 10327 |
Belongs to: |
---|
aldo/keto reductase family |
alcohol dehydrogenase [NADP+]; alcohol dehydrogenase; Aldehyde reductase; Aldo-keto reductase family 1 member A1; aldo-keto reductase family 1, member A1 (aldehyde reductase); ALDR1; ALRMGC1380; ARM; DD3; dihydrodiol dehydrogenase 3; EC 1.1.1; EC 1.1.1.2; MGC12529
Mass (kDA):
36.573 kDA
Human | |
---|---|
Location: | 1p34.1 |
Sequence: | 1; NC_000001.11 (45550779..45570051) |
Widely expressed. Highly expressed in kidney, salivary gland and liver. Detected in trachea, stomach, brain, lung, prostate, placenta, mammary gland, small intestine and lung.
Cytoplasm, cytosol. Apical cell membrane.
PMID: 2498333 by Bohren K.M., et al. The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases.
PMID: 10393438 by Fujii J., et al. The structural organization of the human aldehyde reductase gene, AKR1A1, and mapping to chromosome 1p33-->p32.