AKR7A2 Antibodies

AND AKR7A2 ELISA kits, AKR7A2 Proteins

Many biological assays use antibodies to detect AKR7A2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with AKR7A2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop AKR7A2 antibodies...

We validate the specificity of these antibodies to AKR7A2 by testing them on tissues known to express AKR7A2 positively and negatively. Browse below to find the AKR7A2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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AKR7A2 Infographic by Boster Bio

All AKR7A2 Products

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Anti-AKR7A2 Picoband® Antibody

Western blot analysis of AKR7A2 using anti-AKR7A2 antibody (A06949-1)

IHC analysis of AKR7A2 using anti-AKR7A2 antibody (A06949-1)

Human, Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A06949-1
100 μg/vial

Human Aflatoxin B1 aldehyde reductase member 2/AKR7A2 Recombinant Protein

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain

Enzyme Activity, SDS-PAGE

$265
Cat # PROTO43488
Starting from 20ug

AKR7A2 (NM_003689) Human Over-expression Lysate

Human

$628
Cat # LS008574
20 µg, 100 µg

AKR7A2 Overview

Facts about Aflatoxin B1 aldehyde reductase member 2.

AKR7A2 3D structure. Source: alphafold

Aflatoxin B1 aldehyde reductase member 2 (AKR7A2)

Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in creating the neuromodulator gamma-hydroxybutyrate (GHB).

Has wide substrate specificity. Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro).

Gene Information

Human
Gene Name:	AKR7A2
Uniprot:	O43488
Entrez:	8574

Family

Belongs to:

aldo/keto reductase family

Alternative Names

AFAR1; AFARAFB1-AR1; AFB1 aldehyde reductase 1; AFB1-AR 1; aflatoxin B1 aldehyde reductase member 2; aflatoxin beta1 aldehyde reductase; AKR7; aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase); Aldoketoreductase 7; EC 1.1.1.n11; SSA reductase; Succinic semialdehyde reductase

Molecular Weight

Mass (kDA):
39.589 kDA

Genomic Context


Human

Location:	1p36.13
Sequence:	1; NC_000001.11 (19302708..19312146, complement)

Tissue Specificity

Detected in brain, liver, small intestine and testis, and at lower levels in heart, prostate, skeletal muscle and spleen. Detected in kidney proximal and distal tubules, endothelial cells lining the Bowman's capsules and some cysts. Detected at low levels in lung and pancreas (at protein level). Widely expressed.

Subcellular Localizations

Golgi apparatus. Cytoplasm.

Diseases

Malignant Neoplasms
Neurodegenerative Disorders
Carcinoma
Neoplasms
Neuroblastoma
Endometrial Polyp
Endometrial Carcinoma
Astrocytoma
Liver Diseases
Adenoma
Infectious Mononucleosis
Endometrial Neoplasms
Aneuploidy

Leukemia, Myelocytic, Acute
Alcoholic Liver Diseases
Carcinoma, Pancreatic Ductal
Myeloid Leukemia
Lewy Body Disease
Nervousness
Pancreatic Neoplasm

Interacting Proteins

AKR7A3
CYGB

Pathways

Cell Cycle
Rna Interference
Localization
Secretion
Cell Adhesion
Transport
Dna Replication
Cell Proliferation

Gene Silencing
Cell Death
Cell Motility

PTMs

Reduction

Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AKR7A2

References

PMID: 9576847 by Ireland L.S., et al. Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase.

PMID: 9823300 by Praml C., et al. Cloning of the human aflatoxin B1-aldehyde reductase gene at 1p35- 1p36.1 in a region frequently altered in human tumor cells.