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- Table of Contents
Facts about Aflatoxin B1 aldehyde reductase member 2.
Has wide substrate specificity. Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro).
Human | |
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Gene Name: | AKR7A2 |
Uniprot: | O43488 |
Entrez: | 8574 |
Belongs to: |
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aldo/keto reductase family |
AFAR1; AFARAFB1-AR1; AFB1 aldehyde reductase 1; AFB1-AR 1; aflatoxin B1 aldehyde reductase member 2; aflatoxin beta1 aldehyde reductase; AKR7; aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase); Aldoketoreductase 7; EC 1.1.1.n11; SSA reductase; Succinic semialdehyde reductase
Mass (kDA):
39.589 kDA
Human | |
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Location: | 1p36.13 |
Sequence: | 1; NC_000001.11 (19302708..19312146, complement) |
Detected in brain, liver, small intestine and testis, and at lower levels in heart, prostate, skeletal muscle and spleen. Detected in kidney proximal and distal tubules, endothelial cells lining the Bowman's capsules and some cysts. Detected at low levels in lung and pancreas (at protein level). Widely expressed.
Golgi apparatus. Cytoplasm.
There are many reasons to choose Boster Primary Antibodies, but a high-affinity antibody is a must. This antibody is highly cited in the scientific community and has a long track record for validity. Additionally, it has been validated for use in Western Blotting, Immunohistochemistry, and ELISA. Learn how to use AKR7A2 in your research today!
The AKR7A2 genes is a key regulator of many cellular processes. It is involved in cellular detoxication pathways and may have a protective role against oxidative stress in vivo. This gene has many possible applications in cancer research. Here are some of the Best Uses of the AKR7A2 gene marker. Continue reading to learn more about the gene.
The AKR7A2 gene is expressed in the brain, small intestine, and testis, among other organs. It is also found in the heart (prostate), skeletal muscle, and at lower levels. It can also be found in the Bowman's capsule, endothelial cells, and the Bowman's capsule. It has been extensively investigated in cancer research due to its ability influence recurrence free survival.
The study confirmed that multiple AKR genes were expressed in HCC samples. It also identified potential regulation networks such as DNA methylation or TFs. Superior performance was achieved with a novel risk score model based upon AKR genes. A strong correlation was also found between AKR genes and the tumor immune microenvironment as well as somatic mutations and chemotherapeutic susceptibilities. All data used in the study were obtained from The Cancer Genome Atlas as well as the Gene Expression Omnibus portal.
AKR7A2 comes from the aldoketo reductase superfamily. It is found throughout the body, including in the liver and cerebellum. Ireland et. (2006) discovered a human AFAR gene cDNA derived from the liver, cerebellum and brain. The human AFAR cDNA encoding a 330-amino-acid polypeptide shares 78% identity with rat AFAR. 22% identity is with a Shaker related voltage-gated potassium channel and 16% identity has aldose reductase (103880).
The promoter of the AKR7A2 genome also contained the ERE gene. It is believed that estrogen regulates the gene. This gene was subsequently studied and a gene for AKR7A2 was discovered. One of the most useful uses of the AKR7A2 gene marker is estrogen inhibition. There are currently no treatments for AKR7A2.
XF1729 is a mutation in the AKR7A2 AKR7A2 gene. There are five hundred and twenty-four biological entities associated with this gene. It is involved with the metabolism of steroidal substances. These biological entities comprise approximately half of the human population. The other half of the AKR7A2 family includes the AKR1C protein. These proteins can be related to other AKR genes.
The AKR13B1 Protein is found in various tissues, such as the brain and liver. Boster Bio offers antibodies that are high-affinity to this protein. These antibodies have been validated for use in immunohistochemistry, ELISA, and Western Blotting. Boster Bio can provide the appropriate solution, no matter if you are looking for a monoclonal antibodies or a polyclonal for research use.
The AKR7A2 gene polymorphisms are associated with a variety of biological processes. These biological processes are mediated in part by the AKR enzyme. This enzyme regulates Renin production and secretion. This gene variation is also associated with drug efficacy. Pharmacokinetics and safety. Future research is needed that clarifies the relationship between these genes. Only then can the results be applied to clinical practice.
AKR1B10 is a member of the aldo-keto reductase family. It has been shown to have strong enzymatic activity toward glutathione-conjugated carbonyls. It has been shown in protecting the host cell to prevent toxicity from cytotoxic and cytotoxic carbonyls. This protein is expressed in the intestine.
The AKR7A2 genetic code can be found in many organisms. AKRs include, for example, human aldose reducer, halophilic bacterium diminutase, sea hare norsolorinic acids reductase. Many of these enzymes have crystal structures, which are available through the PDB Web site. Each enzyme has an eight-barrel motif that is conserved at the cofactor binding site and a catalytic triad. The AKR gene is an aldo-keto reductase family protein with variable loop structures defining substrate specificity. The AKR gene group includes a number enzymes that could form multimers in a particular protein.
PMID: 9576847 by Ireland L.S., et al. Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductase.
PMID: 9823300 by Praml C., et al. Cloning of the human aflatoxin B1-aldehyde reductase gene at 1p35- 1p36.1 in a region frequently altered in human tumor cells.