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- Table of Contents
PRKRA Antibodies
AND PRKRA ELISA kits, PRKRA Proteins
Many biological assays use antibodies to detect PRKRA, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PRKRA in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PRKRA antibodies...
Designing an IHC experiment for PRKRA? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PRKRA IHC GuidePRKRA Infographic by Boster Bio
All PRKRA Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A02744-2
100 μg/vial
Cat # A02744-2
100 μg/vial
PRKRA Overview
Facts about Interferon-inducible double-stranded RNA-dependent protein kinase activator A.
Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PRKRA)
Activates EIF2AK2/PKR in the absence of double-stranded RNA (dsRNA), resulting in phosphorylation of EIF2S1/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for following siRNA-mediated post- transcriptional gene silencing.
Doesn't seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53/TP53 association and sumoylation and phosphorylation of p53/TP53 at'Lys-386' in'Ser-392' respectively and enhances its activity at a EIF2AK2/PKR-dependent manner (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | PRKRA |
| Uniprot: | O75569 |
| Entrez: | 8575 |
Family
| Belongs to: |
|---|
| PRKRA family |
Alternative Names
DYT16; DYT16interferon-inducible double stranded RNA-dependent activator; HSD14; PACT; PACTPKR-associating protein X; PKR-associated protein X; PKR-Associating Protein X; PRKRA; protein kinase, interferon-inducible double stranded RNA dependent activator; RAX; RAXHSD14
Molecular Weight
Mass (kDA):
34.404 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q31.2 |
| Sequence: | 2; NC_000002.12 (178431414..178451175, complement) |
Subcellular Localizations
Cytoplasm, perinuclear region. Cytoplasm.
Diseases
- Dystonia Disorders
- Virus Diseases
- Neoplasms
- Secondary Parkinson Disease
- Dystonia, Primary
- Generalized Dystonia
- Malignant Neoplasms
- Congenital Small Ears
- Physiological Stress
- Familial Dystonia
- Movement Disorders
- Immunologic Deficiency Syndromes
Interacting Proteins
- AGO2
- DDX58
- DICER1
- EIF2AK2
- LYAR
- NKRF
- TARBP2
- ZMAT3
Pathways
- Translation
- Rna Interference
- Cell Cycle
- Cell Proliferation
- Mitosis
- Gene Silencing
- Interphase
- Localization
- Cell Death
- Pathogenesis
- Transport
- Cell Differentiation
- Mrna Processing
PTMs
- Phosphorylation
- Cleavage
Research Areas
- Epigenetics
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRKRA
bosterbio.com/bosterbio-gene-info-cards/PRKRA
References
PMID: 9687506 by Patel R.C., et al. PACT, a protein activator of the interferon-induced protein kinase, PKR.
PMID: 10336432 by Ito T., et al. RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling.