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- Table of Contents
Facts about Alpha-aminoadipic semialdehyde dehydrogenase.
Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.
Human | |
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Gene Name: | ALDH7A1 |
Uniprot: | P49419 |
Entrez: | 501 |
Belongs to: |
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aldehyde dehydrogenase family |
aldehyde dehydrogenase 7 family, member A1; Aldehyde dehydrogenase family 7 member A1,26g turgor protein homolog; Alpha-AASA dehydrogenase; ATQ1Antiquitin-1; Betaine aldehyde dehydrogenase; Delta1-piperideine-6-carboxylate dehydrogenase; EC 1.2.1; EC 1.2.1.3; EC 1.2.1.31; EC 1.2.1.8; EPDalpha-aminoadipic semialdehyde dehydrogenase; FLJ11738; FLJ92814; P6c dehydrogenase; PDEantiquitin-1
Mass (kDA):
58.487 kDA
Human | |
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Location: | 5q23.2 |
Sequence: | 5; NC_000005.10 (126541841..126595219, complement) |
Abundant in hepatoma cells and fetal cochlea, ovary, eye, heart, adrenal gland, liver and kidney. Low levels present in adult peripheral blood leukocytes and fetal brain, thymus, spleen, skeletal muscle, lung and tongue.
Cytoplasm, cytosol. Nucleus.; [Isoform 1]: Mitochondrion.
Molecular genetic testing approaches are increasingly used to identify various diseases. This article will examine the benefits and drawbacks of the ALDH7A1 marker. We will also talk about the advantages of boster bio. The ALDH7A1 genes can be found in many types and types of cancers. Below are some of its potential applications:
The most common method of detecting and characterizing genetic changes in genes, proteins, and chromosomes that make up the human gene is called molecular genetics testing. A gene test can confirm that the patient has a diagnosed or suspected genetic disorder and help determine whether the patient is at risk for passing it on to a family member. These tests can identify variations in genetic material and DNA sequences. There are many tests that can be used to analyze a person's entire DNA.
Depending on patient-specific factors, treatment goals, and patient-specific factors, it is important to decide whether you want to go for gene targeted or genomic testing with ALDH7A1 marks. Both methods have their advantages and disadvantages. However, ALDH7A1 genotyping provides the most accurate and complete diagnosis of prostate cancer. Patients may also benefit by targeted therapies to decrease the risk of recurrence.
Presley and colleagues conducted the study to compare the safety and efficacy gene-targeted and genomic testing of ALDH7A1 among patients with advanced NSCLC. The primary outcome was 12-month survival. Flatiron Health Database, which included 5688 patients living with advanced NSCLC, was one of the participants. Subjects were required to submit documented genomic sequencing of the tumor, and EGFR or ALK tests if this was negative.
ALDh2A1 expression in prostate cancer cells is increased in cells that have been enriched for ALDEFLUOR. Chemical inhibition with DEAB of ALDH activation reduced the spherogenicity PCa-cell lines. ALDh2A1 can also be used together with other markers for the identification of PCa cell populations. Qin et al. These markers were combined to identify castration resistant CSCs.
ASCO recognizes that genetic tests are complex and supports high-quality standards. The FDA should look into gene-targeted tests associated with high cancer risk. ASCO is calling for a more patient-centered approach when regulating. Gene-targeted cancer tests should be considered an alternative to genomic cancer tests.
ALDH7A1 is a gene that codes for a protein called a-aminoadipic-semialdehyde dehydrogenase (AASAD). This protein catabolizes Lysine and is essential in many metabolic processes. This protein is essential for cell growth and development. A deficiency can lead to various disorders, including cancer.
Mutations in ALDH7A1 can cause PN dependent epilepsy. This enzyme codes a-aminoadipate. A large percentage of children affected by ALDH7A1 deficiency develop neurodevelopmental problems. Folic acid treatment improves seizure control. These seizures are characterised by a characteristic peak of CSF biogenicamine neurotransmitter testing.
PMID: 8088832 by Lee P., et al. Homology between a human protein and a protein of the green garden pea.
PMID: 9417906 by Skvorak A.B., et al. An ancient conserved gene expressed in the human inner ear: identification, expression analysis, and chromosomal mapping of human and mouse antiquitin (ATQ1).