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ALKBH1 Antibodies
AND ALKBH1 ELISA kits, ALKBH1 Proteins
Many biological assays use antibodies to detect ALKBH1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ALKBH1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ALKBH1 antibodies...
Designing a Western blot for ALKBH1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the ALKBH1 Western Blot GuideALKBH1 Infographic by Boster Bio
All ALKBH1 Products
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ALKBH1 Overview
Facts about Nucleic acid dioxygenase ALKBH1.
Nucleic acid dioxygenase ALKBH1 (ALKBH1)
Dioxygenase that acts as on nucleic acids, such as DNA and tRNA (PubMed:18603530, PubMed:27745969, PubMed:27497299). A number of actions have been described for this dioxygenase, but recent results suggest that it mainly functions as on tRNAs and mediates their demethylation or oxidation depending on the circumstance and subcellular compartment (PubMed:27745969, PubMed:27497299).
Mainly functions as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs, with a preference for N(1)-methyladenine at position 58 (m1A58) present on a stem loop structure of tRNAs (PubMed:27745969). Acts as a regulator of translation initiation and elongation in response to glucose deprivation: modulates both translation initiation, by mediating demethylation of tRNA(Met), and translation elongation, N(1)-methyladenine-containing tRNAs being preferentially recruited to polysomes to promote translation elongation (PubMed:27745969).
Gene Information
| Human | |
|---|---|
| Gene Name: | ALKBH1 |
| Uniprot: | Q13686 |
| Entrez: | 8846 |
Family
| Belongs to: |
|---|
| alkB family |
Alternative Names
ABH1; ABHalkB, alkylation repair homolog (E. coli); alkB; alkB, alkylation repair homolog 1 (E. coli); ALKBH; alkylated DNA repair protein alkB homolog 1; alkylation repair, alkB homolog; Alpha-ketoglutarate-dependent dioxygenase ABH1; DNA lyase ABH1; EC 1.14.11.-; EC 4.2.99.18; hABH
Molecular Weight
Mass (kDA):
43.832 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q24.3 |
| Sequence: | 14; NC_000014.9 (77672404..77708038, complement) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Nucleus. Mitochondrion. Mainly localizes in euchromatin, largely excluded from heterochromatin and nucleoli (By similarity).
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Carcinoma, Transitional Cell
- Microphthalmos
- Anophthalmos
- Neurodegenerative Disorders
- Malignant Neoplasm Of Breast
- Malignant Tumor Of Colon
- Premature Aging Syndrome
- Malignant Neoplasm Of Urinary Bladder
- Malignant Neoplasm Of Lung
Pathways
- Oxidative Demethylation
- Demethylation
- Methylation
- Rna Repair
- Dna Repair
- Dna Alkylation
- Cell Death
- Localization
- Cell Cycle
- Cell Proliferation
- Cell Killing
- Dna Methylation
- Cell Cycle Arrest
PTMs
- Methylation
- Demethylation
Research Areas
- DNA Repair
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ALKBH1
bosterbio.com/bosterbio-gene-info-cards/ALKBH1
References
PMID: 8600462 by Wei Y.F., et al. Molecular cloning and functional analysis of a human cDNA encoding an Escherichia coli AlkB homolog, a protein involved in DNA alkylation damage repair.
PMID: 17979886 by Tsujikawa K., et al. Expression and sub-cellular localization of human ABH family molecules.