This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Protein amnionless.
May direct the creation of back mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (By similarity). .
Human | |
---|---|
Gene Name: | AMN |
Uniprot: | Q9BXJ7 |
Entrez: | 81693 |
Belongs to: |
---|
No superfamily |
Protein amnionless
Mass (kDA):
47.754 kDA
Human | |
---|---|
Location: | 14q32.32 |
Sequence: | 14; NC_000014.9 (102922430..102933597) |
Long isoforms are highly expressed in small intestine, colon and kidney (renal proximal tubule epithelial cells). Shorter isoforms are detected at lower levels in testis, thymus and peripheral blood leukocytes.
[Isoform 1]: Apical cell membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Endosome membrane. Membrane, coated pit.; [Soluble protein amnionless]: Secreted.
PMID: 11279523 by Kalantry S., et al. The amnionless gene, essential for mouse gastrulation, encodes a visceral-endoderm-specific protein with an extracellular cysteine-rich domain.
PMID: 12590260 by Tanner S.M., et al. Amnionless, essential for mouse gastrulation, is mutated in recessive hereditary megaloblastic anemia.