Anaphase-promoting complex subunit 11 (ANAPC11)

Together with the cullin protein ANAPC2, comprises the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a mobile cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complicated acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of'Lys-11'-linked polyubiquitin chains and, to a lesser extent, the formation of'Lys-48'- and'Lys-63'-linked polyubiquitin chains.

May recruit the E2 ubiquitin-conjugating enzymes into the complex. .