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Product Info Summary
| SKU: | A08555-1 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, IF, WB |
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Product info
Product Name
Anti-APC11 ANAPC11 Antibody
SKU/Catalog Number
A08555-1
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-APC11 ANAPC11 Antibody (Catalog # A08555-1). Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
APC11 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-APC11 ANAPC11 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A08555-1)
Host
Rabbit
Contents
APC11 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
APC11 antibody was raised against an 18 amino acid synthetic peptide near the center of human APC11. The immunogen is located within amino acids 70 - 120 of APC11.
Reactive Species
A08555-1 is reactive to ANAPC11 in Human, Mouse, Rat
Observed Molecular Weight
68 kDa
Calculated molecular weight
9.8 kDa
Background of ANAPC11
Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC11 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. APC11, together with APC2 and Ubc4, form the minimal APC ubiquitin ligase module.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A08555-1 is guaranteed for ELISA, IF, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
APC11 antibody can be used for detection of APC11 by Western blot at 1 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in mouse samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of APC11 in HeLa cell lysate with APC11 antibody at 1 μg/mL.
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Immunofluorescence of APC11 in 3T3 cells with APC11 antibody at 20 μg/mL.
Specific Publications For Anti-APC11 ANAPC11 Antibody (A08555-1)
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