Ankyrin-3 Antibodies

AND ANK3 ELISA kits, Ankyrin-3 Proteins

Many biological assays use antibodies to detect Ankyrin-3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ankyrin-3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ankyrin-3 antibodies...

We validate the specificity of these antibodies to Ankyrin-3 by testing them on tissues known to express ANK3 positively and negatively. Browse below to find the ANK3 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ANK3 Infographic by Boster Bio

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Anti-ANK3 Antibody

Human, Mouse, Rat

ELISA, IF, IHC, ICC, WB

$370
Cat # A02066-1
100 μl/vial

ANK3 Overview

Facts about Ankyrin-3.

Ankyrin-3 (ANK3)

In skeletal muscle, required for costamere localization of both DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker.

May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368).

Gene Information

Human
Gene Name:	ANK3
Uniprot:	Q12955
Entrez:	288

Family

Belongs to:

No superfamily

Alternative Names

ankyrin G; Ankyrin G119; ankyrin-3; ankyrin-G; Node Of Ranvier

Molecular Weight

Mass (kDA):
480.41 kDA

Genomic Context


Human

Location:	10q21.2
Sequence:	10; NC_000010.11 (60026298..60733528, complement)

Tissue Specificity

Expressed in brain, neurons, muscles and other tissues.

Subcellular Localizations

Cytoplasm, cytoskeleton. Cell projection, axon. Cell membrane, sarcolemma. Cell junction, synapse, postsynaptic cell membrane. Lysosome. Cell membrane, sarcolemma, T-tubule. In skeletal muscle, localized at costameres and neuromuscular junctions. In macrophages, associated with lysosomes.; [Isoform 5]: Cytoplasm, cytoskeleton. Golgi apparatus.

Diseases

Bipolar Disorder
Schizophrenia
Tissue Adhesions
Depressive Disorder
Major Depressive Disorder
Psychotic Disorders
Mood Disorders
Neoplasms
Borderline Personality Disorder
Nervousness
Dysequilibrium Syndrome
Mental Disorders
Autistic Disorder

Alzheimer's Disease
Epilepsy
Malignant Neoplasms
Manic
Neuroma
Carcinoma
Nervous System Disorder

Interacting Proteins

SMAD2

Pathways

Localization
Transport
Cell Adhesion
Pathogenesis
Cell Cycle
Rna Interference
Cognition
Cell Proliferation
Neurogenesis
Axon Guidance
Interphase
Ammonium Transport
Innervation

Membrane Biogenesis
Synaptic Transmission
Neuroprotection
Protein Targeting
Spermatogenesis
Myelination
Cell Maturation

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ANK3

References

PMID: 7836469 by Kordeli E., et al. AnkyrinG. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier.

PMID: 8666667 by Devarajan P., et al. Identification of a small cytoplasmic ankyrin (AnkG119) in the kidney and muscle that binds beta I sigma spectrin and associates with the Golgi apparatus.