AOC1 Antibodies

Amiloride-sensitive amine oxidase [copper-containing] (AOC1)

Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic reactions and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function.

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Gene Information

Human
Gene Name:	AOC1
Uniprot:	P19801
Entrez:	26

Family

Belongs to:
copper/topaquinone oxidase family

Alternative Names

ABP; ABP1; amiloride binding protein 1 (amine oxidase (copper-containing)); Amiloride-binding protein; amiloride-sensitive amine oxidase [copper-containing]; amiloride-sensitive amine oxidase; AOC1; AOC1DAOamiloride-binding protein-1; DAO1; Diamine Oxidase; EC 1.4.3; EC 1.4.3.22; Histaminase; KAO; Kidney amine oxidase

Molecular Weight

Mass (kDA):
85.378 kDA

Genomic Context

Human
Location:	7q36.1
Sequence:	7; NC_000007.14 (150824875..150861504)

Tissue Specificity

Placenta and kidney.

Subcellular Localizations

Secreted, extracellular space.

Diseases

• Edema
• Fibrosis
• Cystic Fibrosis
• Tissue Adhesions
• Neoplasms
• Malignant Neoplasms
• Dysequilibrium Syndrome
• Allergic Asthma
• Inflammation
• Retinopathy Of Prematurity
• Asthma
• Allergy

• Eosinophilia
• Wiskott-aldrich Syndrome
• Multiple Acyl Coenzyme A Dehydrogenase Deficiency
• Instabilities, Chromosomal
• Neoplasm Metastasis
• Trinucleotide Repeat Expansion
• Malignant Tumor Of Colon

Pathways

• Endocytosis
• Localization
• Transport
• Cell Division
• Cell Cycle
• Receptor-mediated Endocytosis
• Actin Nucleation
• Clathrin-mediated Endocytosis
• Auxin Transport
• Cell Growth
• Chromosome Segregation
• Secretion
• Glycosylation

• Dna Replication
• Cytokinesis
• Mating
• Protein Folding
• Virulence
• Phagocytosis
• Cell Migration

PTMs

• Phosphorylation
• Ubiquitination
• Cleavage
• Glycosylation
• Methylation
• Carboxylation
• Deamination

• Dephosphorylation
• Ribosylation
• Biotinylation
• Reduction
• Farnesylation
• Deacetylation
• Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/AOC1

The Best Uses Of The AOC1 Marker

Steven Boster, the inventor of the AOC1 gene marker has fascinating background. Here, you will learn about his background, research, and career. You can also find out more about the AOC1 genetic gene. This genetic marker can be found in certain types cancer cells and is used for diagnosing the presence of this type of cancer. Boster invented the AOC1 genetic marker in 1993 and has since created hundreds of products for various purposes. By the late 90s, Boster was the largest catalog antibody manufacturer in China. Boster uses a proprietary ELISA platform called PicoKine in order to deliver high-sensitivity ELISA Kits.

Steven Boster

AOC1 is a brand new marker and one of the best uses of a military-style monument. Boster was father to Crystal Boster as well as Natosha Peck. He worked as a manager in retail sales for many years. He was also a U.S. Army Veteran and a Concordia Hall Member in Staunton. In addition, Boster is survived by two sisters, Kimberly Blanton and Tammy Boster, as well as his son Jonathan and his grandson Cory.

The AOC1 was developed by WLLB in Germany. Boster was a major participant in several major battles of the American Civil War. He was also injured in many other battles and was later shot to death at the Battle of Manassas. The AOC1 memorial is a wonderful way to remember loved ones.

The AOC1 serves two main functions. It marks your location on a map. The AOC1 can be used for localization. It can also be used as a marker for landmarks in a town. It can be used for all terrains and its range is approximately one kilometer. The AOC1 is an excellent marker for geocaching within urban environments. The reversible, compass can be used to long-range surveillance.

Steve loved gospel music and enjoyed singing in the back of his car. He was a passionate sports fan and cheered for the opposing team. He also loved auto racing, rarely missing a Friday night race at his local dirt track, and attended a lot of extra events on the weekend. It's no surprise that he took a deep interest in sports throughout his life. His favorite team is also the Dallas Cowboys.

Background

The AOC1 marker's background is still unknown. It has been suggested AOC1 could be involved in polyamine metabolism in Wilms tumors. However, further studies are needed to fully understand its role. The AOC1 genes encode the copper-containing AOC1.

Low clinical outcomes in CRC patients are associated with AOC1 expression. It is therefore possible to use this marker to diagnose patients at risk for CRC. A recent study in The Journal of Hematology showed a correlation between AOC1 levels and the likelihood of developing the disease. This study revealed that patients who underwent CRC surgery had poor prognosis after AOC1 expression.

In vivo experiments showed that AOC1 knockdown reduced tumor growth in tumor cell lines. To test this effect in mice, paired tumor cells were injected into mice and incubated for 48 hrs. The AOC1 knockdown-induced xenograft tumors were significantly smaller than controls. Ki67 staining revealed AOC1 knockdown significantly lowers the number of Ki67 positive cells, inhibiting tumor formation.

WT1 and AOC1 are co-expressed in the same organs. They are closely related. WT1 inhibits protein translation in cultured murine embryonic kidneys. Antisense inhibitors inhibit AOC1 protein translation in cultured murine embryonic kidneys. Double immunofluorescence staining confirmed that Aoc1 protein levels and WT1 protein were co-expressed by the developing genitourinary.

Research

The AOC1 gene can be spliced into two isoforms, WT1[-KTS] and WT1[+KTS]. Inductions WT1[-KTS] increased AOC1 transcripts both in UD28 cells by 3.4fold and 1.1fold, respectively. Induction of WT1(+KTS) did not significantly change AOC1 mRNA levels in UD28 cells.

Knockdown or deletion of AOC1 results in gastric cancer cell migration and invasion. Transwell assays showed that knockdown of AOC1 prevented the invasion and migration of human MKN45 cell lines. Cells in si-AOC1 groups were counted by flow cytometry. All experiments were carried out in triplicates. AOC1 was found to have been upregulated in human gastric carcinoma tissues. Knockdown of AOC1 inhibited cell proliferation, migration, and invasion, and activated the caspase cascade.

The AOC1 gene transcriptional activation regulates putrescine breakdown. Researchers can determine the cause and extent of cancer by altering the expression of the gene. Researchers can improve cancer treatments by studying the effects of AOC1 gene expression on tumor growth. They could also find a drug that targets AOC1 genes in humans. Boster Bio's AOC1 marker can be used to help researchers understand how a certain gene contributes in the development of cancer.

AOC1 co-expression in a murine embryo suggests that it plays a regulatory function. Anti-AOC1 antibodies visualize AOC1 expressing cells in developing kidneys. Anti-WT1 antibodies can detect WT1 in tissue sections from rats and mice. Single immunostainings for WT1 and AOC1 proteins also identified the kidneys, adrenal glands, and mesonephros. AOC1 immunoreactivity in mouse embryos was not observed in normal rabbit serum-containing cells.

Career

The AOC1 gene is an important part of the genitourinary process. The transcription factor regulates putrescine's breakdown. Career uses of this gene include cancer research, immunotherapy, and urology. This gene is a transcription factor with many potential uses. Its role within the human genitourinary and reproductive systems is not well understood. Researchers are becoming more interested in using this gene for therapeutic purposes.

Publications

Gastric cancer tissues have higher levels of AOC1 than normal, healthy tissue. Knockdown of AOC1 significantly decreases the proliferation, invasion and migration of gastric carcinoma cells. Knockdown AOC1 can increase Bax/Bcl2 and inhibit downstream AKT signaling pathways, which in turn promotes apoptosis. AOC1 knockdown can increase E-cadherin while decreasing N cadherin or SNAIL expression.

The AOC1 gene is involved in epithelial-mesenchymal transition (EMT). EMT is characterized by loss of epithelial cell markers and gain of mesenchymal markers. EMT and liver epithelial differentiation are both mediated by polyamines. LOXL2, a copperdependent amine oxidase, has also been implicated as a possible cause of cancer.

Recent research found that AOC1-related poor prognosis was associated with AOC1 upregulation within HCC tissues. AOC1 knockdown resulted in the inhibition of HCC Huh-7 & Hep3B2.1-7 cellular proliferation and invasion. Although further research is needed to confirm this hypothesis, AOC1 could be a potential therapeutic target for HCC. However, this study is important for its implications for cancer prevention and treatment.