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- Table of Contents
Facts about DNA dC->dU-editing enzyme APOBEC-3H.
After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, resulting in G-to-A hypermutations in the subsequent plus-strand viral DNA. The consequent detrimental levels of mutations from the proviral genome, along with a deamination-independent mechanism which works prior to the proviral integration, together exert effective antiretroviral effects in infected target cells.
Human | |
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Gene Name: | APOBEC3H |
Uniprot: | Q6NTF7 |
Entrez: | 164668 |
Belongs to: |
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cytidine and deoxycytidylate deaminase family |
APOBEC-related protein 10; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H; ARP-10; ARP10Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H; DNA dC->dU-editing enzyme APOBEC-3H; EC 3.5.4.-
Mass (kDA):
23.532 kDA
Human | |
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Location: | 22q13.1 |
Sequence: | 22; NC_000022.11 (39097203..39104067) |
Expressed in lymphoid organs. Also detected in non-lymphoid tissues including lung, testis, ovary, fetal liver and skin.
Nucleus. Cytoplasm. Cytoplasm, P-body. Haplotype 1 is distributed in both the nucleus and cytoplasm, whereas haplotype 2 is predominantly cytoplasmic.
PMID: 18945781 by Harari A., et al. Polymorphisms and splice variants influence the antiretroviral activity of human APOBEC3H.
PMID: 12683974 by Wedekind J.E., et al. Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business.