Beta-2-glycoprotein 1 Antibodies

Beta-2-glycoprotein 1 (APOH)

Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.

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Gene Information

Human
Gene Name:	APOH
Uniprot:	P02749
Entrez:	350

Family

Belongs to:
No superfamily

Alternative Names

Activated protein C-binding protein; Anticardiolipin cofactor; APC inhibitor; APOH; apo-H; apolipoprotein H (beta-2-glycoprotein I); Apolipoprotein H; B2G1; B2GP1; B2GPI; Beta; beta(2)GPI; beta-2-glycoprotein 1; Beta-2-glycoprotein I; BG

Molecular Weight

Mass (kDA):
38.298 kDA

Genomic Context

Human
Location:	17q24.2
Sequence:	17; NC_000017.11 (66212033..66229415, complement)

Tissue Specificity

Expressed by the liver and secreted in plasma.

Subcellular Localizations

Secreted.

Diseases

• Autoimmune Reaction
• Malignant Neoplasms
• Neoplasms
• Diabetes Mellitus
• Autoimmune Diseases
• Cardiovascular Diseases
• Lupus Erythematosus, Systemic
• Ischemia
• Diabetes Mellitus, Non-insulin-dependent
• Antiphospholipid Syndrome
• Obesity
• Neoplasm Metastasis

• Fracture Of First Cervical Vertebra
• Metastatic Malignant Neoplasm To The Liver
• Malignant Tumor Of Colon
• Carcinoma Of Unknown Primary
• Persistant Generalized Lymphadenopathy
• Carcinoma
• Acute-phase Reaction

Interacting Proteins

• LDLR
• LPA
• Lrp8
• PF4
• PLG

Pathways

• Coagulation
• Transport
• Translation
• Protein Folding
• Regulation Of Complement Activation
• Reverse Cholesterol Transport
• Complement Activation
• Cholesterol Transport

• Excretion
• Secretion

PTMs

• Oxidation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/APOH

Boster Bio - What Is The APOH Marker?

Boster Bio: PLGMarker is a powerful inhibitor of angiogenesis. This article will explain how this compound works and how to use it. In addition, we'll discuss high-affinity primary antibodies from Boster. Let's get started! - What Is The APOH Marker? What are its best uses and benefits? What are the Best Primary Antibodies for The APOH Marker

Boster Bio PLG Marker is effective inhibitor of angiogenesis

The Boster Bio PLG Marker is a novel, biomaterial system that encapsulates bacterial antigens, GM-CSF, and CpG molecules. PLG inhibits both angiogenesis and neovessel growth in two different ways. It blocks angiogenesis first by inhibiting the growth neonessels. It also prevents inflammatory cell migration and recruitment. It also has many other uses.

Angiogenesis is the process by which cells in a tissue form new blood vessels. Angiogenesis is an especially skilled process for cancerous tumors. This is because they have a greater supply of blood, which allows them to grow quickly. Cancer cells send chemical signals that trigger the production of angiogenesis signaling proteins to nearby tissues. The tumor grows and invades surrounding tissue with the help of new blood vessels. These new blood vessels facilitate the proliferation and spread of cancer cells.

Bevacizumab (the first angiogenesis inhibitor approved) inhibits osteosarcoma growth in a nude mouse. It also inhibits osteosarcomaangiogenesis which is a key step in the progression and progression of osteosarcoma. Serum, which is rich in extracellular vesicles, is thought to have pro-angiogenic benefits.

Angiogenesis inhibiters are designed to prevent the growth of tumors through blocking their blood supply. Angiogenesis inhibitors reduce the production and supply of new blood vessels. This effectively stops the cancer from receiving its blood supply. Although angiogenesis inhibitors are effective in treating cancers, their effectiveness can vary. They are most effective in cancerous tissues, such as the liver and kidney tumors, as well as neuroendocrine tumours.

Angiogenesis inhibitors reduce the growth of tumors via blocking signaling pathways that are triggered by proangiogenic compounds. VEGFA, VEGFR are the most common anti-angiogenic agents that have been approved for use in cancer. The VEGFA-targeted monoclonal antibodies bevacizumab are the leaders in this field. Look no further if your search for an angiogenesis inhibitor is unsuccessful. This biotech-based agent inhibits tumor angiogenesis in a variety of cancers.

The APOH Marker works as an effective inhibitor against angiogenesis

The lack of an effective biomarker to assess angiogenesis is a significant problem in the treatment of cancer. Traditional cytotoxic drugs are titrated to the maximum tolerated dosage in a certain population. Targeted therapies may reach therapeutic doses before side effects start to occur. One type of targeted therapy is angiogenesis inhibitors. The only available angiogenesis inhibitors currently available are cytostatic. They cause changes in the vessel structure but not direct tumor killing. Investigators are currently searching for a biomarker to help them assess angiogenesis in cancer.

Inhibitors that block angiogenesis interfere with the growth of blood vessels by interfering in several steps. Some bind with VEGF receptors to prevent VEGF activated. Others target other receptors on endothelial cells or downstream signaling pathways. Others are immunomodulatory drugs with antiangiogenic effects. These compounds inhibit angiogenesis by blocking activity of a specific protein in the tumor microenvironment.

Angiogenesis is a complex process that takes place within the body. To produce a new blood vessel, a series of molecules called angiopoietins must first be expressed on the tumor's surface. Angiopoietins bind to the Tie-2 receptor and serve as a signaling component for the cells' growth. Endothelial cells then migrate out of the capillary walls and proliferate elsewhere due to the angiogenic factors. They also express Integrins which facilitate migration and tube formation. APOH Marker can be used as an effective inhibitor to angiogenesis.

Studies have shown that blocking the expression of angiogenic receptors, such VEGF/VEGF, can make angiopoietin-like receptors (HIF-1 and VEGF) more effective than anti VEGF treatment alone. It is possible to believe that COX-2 inhibitors could be a systemic target in diabetic patients.

The results of the study suggest that APOH-exos may be a core protein of APS. In the mouse model APS-exos were shown to suppress migration and tube growth of HUVECs. The researchers discovered 27 upregulated and 9 downregulated proteins by quantitative proteomics. APOH is believed to act through the phospho-extracellular signal-regulated kinase pathway.

Apoptosis in tumors may be suppressed by inhibition of angiogenesis. Furthermore, tumors can increase their susceptibility to radiation. It is important to find a drug that can decrease tumor growth and inhibit angiogenesis. This drug has the potential to be a valuable therapy for cancer patients. Side effects of anti-angiogenic drugs are still unknown.

Boster sells high-affinity prim antibodies

Boster Bio lab produces high-affinity ELISA kits and primary antibodies for a wide variety of applications. Its products have been thoroughly tested for ELISA or WB applications. The company provides antibodies and ELISA kits for research purposes, including cancer, neuroscience, and inflammation. Boster Bio offers samples from mice and humans, as well a variety of secondary antibodies.

Boster Bio tests its high-affinity prim antibodies for efficiency, sensitivity and specificity. Boster Bio offers both liquid and solid products for IHC/WB analysis. The company also offers customized services as well as BeNeLux deliveries. Boster Bio can provide high-affinity primary antibodies through custom orders. Boster Bio can help with your research questions.

Primary antibodies are immunoglobulins designed to bind specific antigens. Their specificity and affinity, which measure the number of unintended antibodies they bind to, are usually indicators of their quality. Higher affinity indicates higher specificity. Lower specificity indicates lower quality. High-affinity primary antibody are useful for measuring, purifying and detecting specific proteins. Flowcytometry is a widely used technique in many research fields.

Human antibodies are highly targeted against a specific type of antigen. Because they don't induce HAMA (homogeneous Antigen-mediated Immunity), human antibodies are much more effective than those from murine animals. Furthermore, human antibodies can recognize subtle therapeutic epitopes, which murine antibodies may not be able to detect. These subtle targets are better recognized by the immune system of the human being. Ultimately, high-affinity primary antibodies are beneficial for research.

Boster Bio offers high affinity primary antibodies that are suitable for research. It uses the body’s natural immune system to generate antibodies with high affinity. Its research produces clinical trials, drug discovery, and molecule tools that are useful for the neuroscience community. The company is committed to producing and commercializing antibodies. This innovative technology will ultimately be of benefit to patients. These antibodies can fight diabetes, cancer, and other diseases.

High-affinity primaries antibodies can be used for human disease treatment. These antibodies are effective against viral, bacterial and yeast infections. They are also highly sensitive. Boster Bio offers high affinity primary antibodies for clinical trials. They will also aid researchers in identifying disease-related proteins. They will also enable them to screen cancerous and resistant viruses.