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- Table of Contents
Facts about Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3.
Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Founded on ARF6, RAC1, RHOA and CDC42.
Human | |
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Gene Name: | ARAP3 |
Uniprot: | Q8WWN8 |
Entrez: | 64411 |
Belongs to: |
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No superfamily |
Arf and Rho GAP adapter protein 3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3; ARF-GAP, RHO-GAP, ankyrin repeat and plekstrin homology domains-containingprotein 3; centaurin, delta 3; centaurin-delta-3; CENTD3; cnt-d3; DRAG1; FLJ21065; phosphoinositide binding protein; PtdIns(34,5)P3-binding protein
Mass (kDA):
169.844 kDA
Human | |
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Location: | 5q31.3 |
Sequence: | 5; NC_000005.10 (141653401..141682230, complement) |
Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein. Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasmic, and associated with F-actin-rich membrane ruffles and lamellipodia.
PMID: 11804589 by Krugmann S., et al. Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices.
PMID: 12015138 by Santy L.C., et al. GTPase signaling: bridging the GAP between ARF and Rho.