Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (ARAP3)

Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein which modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding.

Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Founded on ARF6, RAC1, RHOA and CDC42.