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- Table of Contents
Facts about Rho GTPase-activating protein 21.
Functions as a GTPase-activating protein (GAP) for RHOA and CDC42.
Downstream partner of ARF1 which may control Golgi apparatus structure and function.Also necessary for CTNNA1 recruitment to adherens junctions. .
Human | |
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Gene Name: | ARHGAP21 |
Uniprot: | Q5T5U3 |
Entrez: | 57584 |
Belongs to: |
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No superfamily |
DKFZp761L0424; FLJ33323; FLJ90108; KIAA1424; Rho GTPase activating protein 21; rho GTPase-activating protein 10; rho GTPase-activating protein 21; Rho-GTPase activating protein 10; rho-type GTPase-activating protein 21
Mass (kDA):
217.462 kDA
Human | |
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Location: | 10p12.1|10p12.3 |
Sequence: | 10; NC_000010.11 (24583610..24725421, complement) |
Widely expressed with higher expression in brain, heart, skeletal muscle and placenta.
Golgi apparatus membrane; Peripheral membrane protein. Cell junction. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Localization to the Golgi is dependent on interaction with GTP-bound ARF1.
PMID: 12056806 by Basseres D.S., et al. ARHGAP10, a novel human gene coding for a potentially cytoskeletal Rho-GTPase activating protein.
PMID: 15375573 by Katoh M., et al. Characterization of human ARHGAP10 gene in silico.