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- Table of Contents
Facts about Rho GTPase-activating protein 24.
Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to accomplish cellular polarity. Able to suppress RAC1 and CDC42 action in vitro.
| Human | |
|---|---|
| Gene Name: | ARHGAP24 |
| Uniprot: | Q8N264 |
| Entrez: | 83478 |

| Belongs to: |
|---|
| No superfamily |

DKFZP564B1162; Filamin-A-associated RhoGAP; FilGAP; FILGAPRCGAP72; FLJ33877; p73; p73RhoGAP; RAC1- and CDC42-specific GTPase-activating protein of 72 kDa; RC-GAP72; Rho GTPase activating protein 24; rho GTPase-activating protein 24; RhoGAP of 73 kDa; Rho-type GTPase-activating protein 24; Sarcoma antigen NY-SAR-88
Mass (kDA):
84.258 kDA

| Human | |
|---|---|
| Location: | 4q21.23-q21.3 |
| Sequence: | 4; NC_000004.12 (85475150..86002666) |
Isoform 1 is widely expressed with a higher level in kidney. Isoform 2 is mainly expressed in endothelial cells.
Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell junction, focal adhesion. Cell projection. Localizes to actin stress fibers. In migrating cells, localizes to membrane lamellae and protusions.





PMID: 12601173 by Lee S.-Y., et al. Immunomic analysis of human sarcoma.
PMID: 15254788 by Katoh M., et al. Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico.