Rho GTPase-activating protein 24 (ARHGAP24)

Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it into an inactive GDP-bound state.

Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to accomplish cellular polarity. Able to suppress RAC1 and CDC42 action in vitro.