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- Table of Contents
Facts about Rho GTPase-activating protein 29.
May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis.
Human | |
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Gene Name: | ARHGAP29 |
Uniprot: | Q52LW3 |
Entrez: | 9411 |
Belongs to: |
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No superfamily |
PARG1PTPL1-associated RhoGAP 1 (PARG1); PTPL1-associated RhoGAP protein 1; Rho GTPase activating protein 29; rho GTPase-activating protein 29; Rho-type GTPase-activating protein 29; RP11-255E17.1
Mass (kDA):
142.064 kDA
Human | |
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Location: | 1p22.1 |
Sequence: | 1; NC_000001.11 (94168905..94275068, complement) |
Widely expressed. Highly expressed in skeletal muscle and heart. Expressed at intermediate level in placenta, liver and pancreas. Weakly expressed in brain, lung and kidney.
PMID: 9305890 by Saras J., et al. A novel GTPase-activating protein for Rho interacts with a PDZ domain of the protein-tyrosine phosphatase PTPL1.
PMID: 11716068 by Mariani L., et al. Glioma cell motility is associated with reduced transcription of proapoptotic and proliferation genes: a cDNA microarray analysis.