Rho GTPase-activating protein 29 (ARHGAP29)

GTPase activator for the Rho-type GTPases by turning them into an inactive GDP-bound state. Has strong action toward RHOA, and weaker action toward RAC1 and CDC42.

May act as a specific effector of RAP2A to regulate Rho. In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis.