Rho GTPase-activating protein 44 (ARHGAP44)

GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP- bound states.

May act as a GAP for CDC42 and RAC1. Endosomal recycling protein which, in conjunction with SHANK3, is involved in synaptic plasticity.