This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Rho GTPase-activating protein 44.
May act as a GAP for CDC42 and RAC1. Endosomal recycling protein which, in conjunction with SHANK3, is involved in synaptic plasticity.
Human | |
---|---|
Gene Name: | ARHGAP44 |
Uniprot: | Q17R89 |
Entrez: | 9912 |
Belongs to: |
---|
No superfamily |
Rho GTPase activating protein 44; rho GTPase-activating protein RICH2
Mass (kDA):
89.247 kDA
Human | |
---|---|
Location: | 17p12 |
Sequence: | 17; NC_000017.11 (12789498..12991644) |
Highly expressed in brain. Expressed at weak level in other tissues.
Cell projection, dendritic spine. Recycling endosome. Cell junction, synapse, presynapse. Cell projection, dendrite. In CA1 hippocampal synapses, detected at both presynaptic and postsynaptic sites (By similarity). Located in convoluted dendritic plasma membrane sections enriched in polymerized actin and myosin (patches) along dendrites where often emerge filopodia (By similarity).
PMID: 11431473 by Richnau N., et al. Rich, a rho GTPase-activating protein domain-containing protein involved in signaling by Cdc42 and Rac1.
PMID: 19273615 by Rollason R., et al. A CD317/tetherin-RICH2 complex plays a critical role in the organization of the subapical actin cytoskeleton in polarized epithelial cells.