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ARPC1B Antibodies
AND ARPC1B ELISA kits, ARPC1B Proteins
Many biological assays use antibodies to detect ARPC1B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ARPC1B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ARPC1B antibodies...
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ARPC1B Infographic by Boster Bio
All ARPC1B Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IP, IHC, WB
$370
Cat # A07192-2
100 μg/vial
Cat # A07192-2
100 μg/vial
ARPC1B Overview
Facts about Actin-related protein 2/3 complex subunit 1B.
Actin-related protein 2/3 complex subunit 1B (ARPC1B)
Part of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation- promoting factor (NPF) (PubMed:11741539, PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:11741539, PubMed:9230079).
Besides its function in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, resulting in drive motility of double-strand breaks (DSBs) (PubMed:29925947).
Gene Information
| Human | |
|---|---|
| Gene Name: | ARPC1B |
| Uniprot: | O15143 |
| Entrez: | 10095 |
Family
| Belongs to: |
|---|
| WD repeat ARPC1 family |
Alternative Names
actin related protein 2/3 complex, subunit 1B (41 kD); actin related protein 2/3 complex, subunit 1B, 41kDa; actin-related protein 2/3 complex subunit 1B; ARC41p41-ARCp40-ARC; Arp2/3 complex 41 kDa subunit; ARP2/3 protein complex subunit p41
Molecular Weight
Mass (kDA):
40.95 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q22.1 |
| Sequence: | 7; NC_000007.14 (99374254..99394816) |
Subcellular Localizations
Cytoplasm, cytoskeleton. Nucleus.
Diseases
- Malignant Neoplasms
- Stomach Neoplasms
- Neoplasms
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Stomach
- Neoplasm Metastasis
- Oncogene Activation Process
- Melanoma
- Malignant Neoplasm Of Breast
- Bone Neoplasms
- Malignant Neoplasm Of Lung
- Carcinoma
Interacting Proteins
- ARPC3
Pathways
- Methylation
- Cell Cycle
- Senescence
- Cell Migration
- Cell Motility
- Locomotion
- Cellular Senescence
- Regulation Of Mitosis
- Mitosis
PTMs
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ARPC1B
bosterbio.com/bosterbio-gene-info-cards/ARPC1B
References
PMID: 9230079 by Welch M.D., et al. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly.
PMID: 11741539 by Gournier H., et al. Reconstitution of human Arp2/3 complex reveals critical roles of individual subunits in complex structure and activity.