Beclin 1-associated autophagy-related key regulator (ATG14)

Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complicated PI3KC3-C1 (PubMed:18843052, PubMed:19050071).

Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi system to autophagosomes (PubMed:20713597).