Ataxin-7 Antibodies

AND ATXN7 ELISA kits, Ataxin-7 Proteins

Many biological assays use antibodies to detect Ataxin-7, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ataxin-7 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ataxin-7 antibodies...

We validate the specificity of these antibodies to Ataxin-7 by testing them on tissues known to express ATXN7 positively and negatively. Browse below to find the ATXN7 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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ATXN7 Infographic by Boster Bio

All ATXN7 Products

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Anti-Ataxin-7 ATXN7 Antibody

Western blot (WB) analysis of ATXN7 polyclonal antibody at 1:500 dilution
Lane1:A549 whole cell lysate
Lane2:NIH-3T3 whole cell lysate
Lane3:PC12 whole cell lysate

Human, Mouse

$405
Cat # A02936
100ul

Anti-Mouse Atxn7 Antibody

Western blot analysis of Atxn7 using anti-Atxn7 antibody (DZ41648)

Mouse

$470
Cat # DZ41648
200 μl/vial

ATXN7 Overview

Facts about Ataxin-7.

ATXN7 3D structure. Source: alphafold

Ataxin-7 (ATXN7)

Acts as component of the STAGA transcription coactivator-HAT complex. Mediates the interaction of STAGA complex with the CRX and is involved in CRX-dependent gene activation.

Necessary for microtubule cytoskeleton stabilization. .

Gene Information

Human
Gene Name:	ATXN7
Uniprot:	O15265
Entrez:	6314

Family

Belongs to:

ataxin-7 family

Alternative Names

ADCAII; ataxin 7; FLJ17787; SCA7

Molecular Weight

Mass (kDA):
95.451 kDA

Genomic Context


Human

Location:	3p14.1
Sequence:	3; NC_000003.12 (63863144..64003462)

Tissue Specificity

Isoform a and isoform b are expressed in CNS, but isoform a is expressed predominantly in the peripherical tissues. Isoform b is also highly expressed in the frontal lobe, skeletal muscle and spinal cord and is expressed at a lower level in the lung, lymphoblast and intestine.

Subcellular Localizations

[Isoform a]: Nucleus. Nucleus, nucleolus. Nucleus matrix. Cytoplasm, cytoskeleton. In addition to a diffuse distribution throughout the nucleus, it is associated with the nuclear matrix and the nucleolus. It is able to shuttle between the nucleus and cytoplasm.; [Isoform b]: Cytoplasm.

Diseases

Ataxia
Ataxia, Spinocerebellar
Spinocerebellar Ataxia Type 7
Neurodegenerative Disorders
Trinucleotide Repeat Expansion
Retinal Degeneration
Nerve Degeneration
Cerebellar Ataxia
Hereditary Ataxia, Unspecified
Friedreich Ataxia
Abnormal Degeneration
Dentatorubral-pallidoluysian Atrophy

Genomic Instability
Pure Autonomic Failure
Atrophy
Age Related Macular Degeneration
Dyskinetic Syndrome
Secondary Parkinson Disease
Multiple System Atrophy

Interacting Proteins

AGRN
CEP72
LTBP4
MATN2
MEGF6

MEGF8
NOC2L
NUP62
SIAH1
SORBS1

TAF10
TRRAP

Pathways

Pathogenesis
Histone Acetylation
Localization
Cell Division
Cell Migration
Cell Death
Locomotion

Dna Repair
Autophagy

PTMs

Acetylation
Ubiquitination

Sumoylation
Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ATXN7

References

PMID: 9288099 by David G., et al. Cloning of the SCA7 gene reveals a highly unstable CAG repeat expansion.

PMID: 9425224 by Del-Favero J., et al. Molecular genetic analysis of autosomal dominant cerebellar ataxia with retinal degeneration (ADCA type II) caused by CAG triplet repeat expansion.