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- Table of Contents
BCAR3 Antibodies
AND BCAR3 ELISA kits, BCAR3 Proteins
Many biological assays use antibodies to detect BCAR3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BCAR3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BCAR3 antibodies...
Designing a Western blot for BCAR3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the BCAR3 Western Blot GuideBCAR3 Infographic by Boster Bio
All BCAR3 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA
$480
Cat # EKC1652
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1652
1 kit, containing one 96-well plate and all necessary reagents
BCAR3 Overview
Facts about Breast cancer anti-estrogen resistance protein 3.
Breast cancer anti-estrogen resistance protein 3 (BCAR3)
May act as an adapter protein and couple activated growth factor receptors to a signaling pathway that regulates the proliferation in breast cancer cells. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines.
May also be regulated by cellular adhesion to extracellular matrix proteins. .
Gene Information
| Human | |
|---|---|
| Gene Name: | BCAR3 |
| Uniprot: | O75815 |
| Entrez: | 8412 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
breast cancer estrogen resistance 3; dJ1033H22.2 (breast cancer estrogen resistance 3); KIAA0554; Novel SH2-containing protein 2; NSP2SH2D3Bbreast cancer estrogen resistance protein 3; SH2 domain-containing protein 3B
Molecular Weight
Mass (kDA):
92.566 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p22.1 |
| Sequence: | 1; NC_000001.11 (93561741..93847219, complement) |
Subcellular Localizations
Cytoplasm. Cell junction, focal adhesion. Localization to focal adhesions depends on interaction with PTPRA.
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Tissue Adhesions
- Mammary Neoplasms
- Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Neoplasm Invasiveness
- Mammary Neoplasms, Experimental
- Cell Invasion
- Laryngeal Squamous Cell Carcinoma
Interacting Proteins
- BCAR1
- ERBB2
- IRS1
- KIT
- NEDD9
- OSGIN1
Pathways
- Cell Proliferation
- Cell Adhesion
- Cell Migration
- Cell Motility
- Localization
- Cell Cycle
- Cell Growth
- Transport
- Osteoclast Differentiation
- Hyperphosphorylation
- Osteoclast Development
- Sex Determination
- Cell Cycle Arrest
PTMs
- Phosphorylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BCAR3
bosterbio.com/bosterbio-gene-info-cards/BCAR3
References
PMID: 9582273 by van Agthoven T., et al. Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells.
PMID: 10187783 by Lu Y., et al. NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress- activated protein kinase signaling pathway.