Anti-BCAR3 Antibody Picoband™

BCAR3 antibody

Boster Bio Anti-BCAR3 Antibody Picoband™ catalog # PB9846. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Info Summary

SKU: PB9846
Size: 100 μg/vial
Reactive Species: Human, Mouse, Rat
Host: Rabbit
Application: IHC, WB

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Product Name

Anti-BCAR3 Antibody Picoband™

View all BCAR3 Antibodies

SKU/Catalog Number

PB9846

Size

100 μg/vial

Form

Lyophilized

Description

Boster Bio Anti-BCAR3 Antibody Picoband™ catalog # PB9846. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Storage & Handling

Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-BCAR3 Antibody Picoband™ (Boster Biological Technology, Pleasanton CA, USA, Catalog # PB9846)

Host

Rabbit

Contents

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Clonality

Polyclonal

Isotype

Rabbit IgG

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminus of human BCAR3, different from the related mouse sequence by five amino acids.

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Cross-reactivity

No cross-reactivity with other proteins.

Reactive Species

PB9846 is reactive to BCAR3 in Human, Mouse, Rat

Applications

PB9846 is guaranteed for IHC, WB Boster Guarantee

Observed Molecular Weight

93 kDa

Calculated molecular weight

92.566kDa

Background of BCAR3

Breast cancer anti-estrogen resistance protein 3 is a protein that in humans is encoded by the BCAR3 gene. Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Innovating Scientists Reward

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Reconsitution

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Mouse, Rat, By Heat
Western blot, 0.1-0.5μg/ml, Human

Validation Images & Assay Conditions

Gene/Protein Information For BCAR3 (Source: Uniprot.org, NCBI)

Gene Name

BCAR3

Full Name

Breast cancer anti-estrogen resistance protein 3

Weight

92.566kDa

Alternative Names

breast cancer estrogen resistance 3; dJ1033H22.2 (breast cancer estrogen resistance 3); KIAA0554; Novel SH2-containing protein 2; NSP2SH2D3Bbreast cancer estrogen resistance protein 3; SH2 domain-containing protein 3B BCAR3 AND-34, MIG7, NSP2, SH2D3B BCAR3 adaptor protein, NSP family member breast cancer anti-estrogen resistance protein 3|BCAR3, NSP family adaptor protein|SH2 domain-containing protein 3B|breast cancer anti-estrogen resistance 3|breast cancer antiestrogen resistance 3 protein|dJ1033H22.2 (breast cancer anti-estrogen resistance 3)|epididymis secretory sperm binding protein|mig-7|migration inducting gene-7|novel SH2-containing protein 2

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on BCAR3, check out the BCAR3 Infographic

BCAR3 infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for BCAR3: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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4 Customer Q&As for Anti-BCAR3 Antibody Picoband™

Question

I was wanting to use your anti-BCAR3 antibody for WB for rat cervix carcinoma on frozen tissues, but I want to know if it has been validated for this particular application. Has this antibody been validated and is this antibody a good choice for rat cervix carcinoma identification?

Verified Customer

Verified customer

Asked: 2020-01-10

Answer

As indicated on the product datasheet, PB9846 anti-BCAR3 antibody has been tested for IHC, WB on human, mouse, rat tissues. We have an innovator award program that if you test this antibody and show it works in rat cervix carcinoma in IHC-frozen, you can get your next antibody for free.

Boster Scientific Support

Answered: 2020-01-10

Question

My question regards to test anti-BCAR3 antibody PB9846 on rat cervix carcinoma for research purposes, then I may be interested in using anti-BCAR3 antibody PB9846 for diagnostic purposes as well. Is the antibody suitable for diagnostic purposes?

Verified Customer

Verified customer

Asked: 2020-01-09

Answer

The products we sell, including anti-BCAR3 antibody PB9846, are only intended for research use. They would not be suitable for use in diagnostic work. If you have the means to develop a product into diagnostic use, and are interested in collaborating with us and develop our product into an IVD product, please contact us for more discussions.

Boster Scientific Support

Answered: 2020-01-09

Question

We are currently using anti-BCAR3 antibody PB9846 for mouse tissue, and we are content with the IHC results. The species of reactivity given in the datasheet says human, mouse, rat. Is it true that the antibody can work on zebrafish tissues as well?

Verified Customer

Verified customer

Asked: 2019-11-28

Answer

The anti-BCAR3 antibody (PB9846) has not been validated for cross reactivity specifically with zebrafish tissues, but there is a good chance of cross reactivity. We have an innovator award program that if you test this antibody and show it works in zebrafish you can get your next antibody for free. Please contact me if I can help you with anything.

Boster Scientific Support

Answered: 2019-11-28

Question

Does anti-BCAR3 antibody PB9846 work on feline IHC with lung?

R. Singh

Verified customer

Asked: 2016-03-10

Answer

Our lab technicians have not tested anti-BCAR3 antibody PB9846 on feline. You can run a BLAST between feline and the immunogen sequence of anti-BCAR3 antibody PB9846 to see if they may cross-react. If the sequence homology is close, then you can perform a pilot test. Keep in mind that since we have not validated feline samples, this use of the antibody is not covered by our guarantee. However we have an innovator award program that if you test this antibody and show it works in feline lung in IHC, you can get your next antibody for free.

Boster Scientific Support

Answered: 2016-03-10

Order DetailsPrice
PB9846

100μg

$370
PB9846-10ug

10μg sample (liquid)

$99
PB9846-Biotin

100 μg Biotin conjugated

$570
PB9846-Cy3

100 μg Cy3 conjugated

$570
PB9846-Dylight488

100 μg Dylight488 conjugated

$570
PB9846-Dylight550

100 μg Dylight550 conjugated

$570
PB9846-Dylight594

100 μg Dylight594 conjugated

$570
PB9846-FITC

100 μg FITC conjugated

$570
PB9846-HRP

100 μg HRP conjugated

$570
PB9846-APC

100 μg APC conjugated

$670
PB9846-PE

100 μg PE conjugated

$670
PB9846-carrier-free

Carrier Free

$370

More conjugates/formats

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Buy one primary antibody get one 0.5ml HRP or Biotin secondary antibody for free.
*Sample sizes are prepared on demand and will take extra lead time. (cannot be conjugated)
$370.00

Troubleshooting

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