- Table of Content
During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P- TEFb complex and recruitment it to promoters: BRD4 is required to form the transcriptionally active P-TEFb complicated by displacing negative regulators such as HEXIM1 and 7SKsnRNA complicated from P- TEFb, thereby transforming it into an active form which can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II. According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of'Ser-2' of this C-terminal domain (CTD) of RNA polymerase II; these data nevertheless need additional evidences in vivo (PubMed:22509028).
|Sequence:||19; NC_000019.10 (15236836..15332539, complement)|
Nucleus. Chromosome. Associates with acetylated chromatin (PubMed:21890894, PubMed:16109376). Released from chromatin upon deacetylation of histones that can be triggered by different signals such as activation of the JNK pathway or nocodazole treatment (PubMed:21890894, PubMed:16109376). Preferentially localizes to mitotic chromosomes, while it does not localizes to meiotic chromosomes (PubMed:21890894, PubMed:16109376).; [Isoform B]: Chromosome.