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- Table of Contents
BTK Antibodies
AND BTK ELISA kits, BTK Proteins
Many biological assays use antibodies to detect BTK, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with BTK in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop BTK antibodies...
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BTK Infographic by Boster Bio
All BTK Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA
$480
Cat # EKC1068
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1068
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC1972
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC1972
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse
ELISA, IF, IHC-P, ICC, WB
$481
Cat # A00245
0.1 mg
Cat # A00245
0.1 mg
Human, Monkey
ELISA, IF, IHC, WB
$380
Cat # M00245-1
100ul
Cat # M00245-1
100ul
Human, Mouse, Rat
Flow Cytometry, IF, IHC, WB
$523
Cat # M00245-2
100 µl
Cat # M00245-2
100 µl
Human
ELISA, IP, IF, IHC, WB
$146
Cat # M00245-4
20μL, 40μL, 100μL, 200μL
Cat # M00245-4
20μL, 40μL, 100μL, 200μL
BTK Overview
Facts about Tyrosine-protein kinase BTK.
Tyrosine-protein kinase BTK (BTK)
Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation.
Following BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at many sites, sparking the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is done in close collaboration with the adapter protein B-cell linker protein BLNK.
Gene Information
| Human | |
|---|---|
| Gene Name: | BTK |
| Uniprot: | Q06187 |
| Entrez: | 695 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
Agammaglobulinaemia tyrosine kinase; AGMX1; AGMX1MGC126262; AT; ATKIMD1; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia tyrosine kinase; Bruton tyrosine kinase; BTK; dominant-negative kinase-deficient Brutons tyrosine kinase; EC 2.7.10; EC 2.7.10.2; IMD1; PSCTK1; tyrosine-protein kinase BTK; XLA; XLAMGC126261
Molecular Weight
Mass (kDA):
76.281 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xq22.1 |
| Sequence: | X; NC_000023.11 (101349447..101390796, complement) |
Tissue Specificity
Predominantly expressed in B-lymphocytes.
Subcellular Localizations
Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus. In steady state, BTK is predominantly cytosolic. Following B-cell receptor (BCR) engagement by antigen, translocates to the plasma membrane through its PH domain. Plasma membrane localization is a critical step in the activation of BTK. A fraction of BTK also shuttles between the nucleus and the cytoplasm, and nuclear export is mediated by the nuclear export receptor CRM1.
Diseases
- Agammaglobulinemia
- X-linked Agammaglobulinemia
- Immunologic Deficiency Syndromes
- Leukemia
- Infective Disorder
- Genetic Diseases, X-linked
- Lymphoma
- Malignant Neoplasms
- Primary Immune Deficiency Disorder
- Neoplasms
- Bacterial Infections
- B-cell Lymphomas
- Inflammation
Interacting Proteins
- ARID3A
- BLNK
- GTF2I
- HSP90AB1
- MAL
- MEOX2
- PRKCQ
- SH3BP5
- WAS
Pathways
- Cell Development
- Secretion
- Cell Activation
- Cell Differentiation
- Localization
- Cytokine Production
- B Cell Differentiation
- Pathogenesis
- Cell Death
- Cell Proliferation
- Immune Response
- B Cell Activation
- B Cell Proliferation
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
- Methylation
- Acetylation
Research Areas
- Immunology
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BTK
bosterbio.com/bosterbio-gene-info-cards/BTK
References
PMID: 8380905 by Vetrie D., et al. The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases.
PMID: 8090769 by Ohta Y., et al. Genomic organization and structure of Bruton agammaglobulinemia tyrosine kinase: localization of mutations associated with varied clinical presentations and course in X chromosome-linked agammaglobulinemia.