This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Cell adhesion molecule 1 Antibodies
AND CADM1 ELISA kits, Cell adhesion molecule 1 Proteins
Many biological assays use antibodies to detect Cell adhesion molecule 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cell adhesion molecule 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cell adhesion molecule 1 antibodies...
Designing a Western blot for Cell adhesion molecule 1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CADM1 Western Blot GuideCADM1 Infographic by Boster Bio
All CADM1 Products
Product
Figures
Specificity
Applications
Price
CADM1 Overview
Facts about Cell adhesion molecule 1.
Cell adhesion molecule 1 (CADM1)
Mediates homophilic cell-cell adhesion in a Ca(2+)- independent manner. Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner.
Acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo.
Gene Information
| Human | |
|---|---|
| Gene Name: | CADM1 |
| Uniprot: | Q9BY67 |
| Entrez: | 23705 |
Family
| Belongs to: |
|---|
| nectin family |
Alternative Names
BL2; Cadm1; cell adhesion molecule 1; IgSF4; IGSF4A; IGSF4ADKFZp686F1789; IGSF4immunoglobulin superfamily, member 4D variant 2; Immunoglobulin superfamily member 4; immunoglobulin superfamily, member 4; Necl-2; NECL2MGC149785; nectin-like 2; Nectin-like protein 2; RA175; sgIGSF; Spermatogenic immunoglobulin superfamily; ST17; sTSLC-1; Synaptic cell adhesion molecule; SynCAM; SynCAM1; SYNCAMMGC51880; TSLC1; TSLC-1; TSLC1/Nectin-like 2/IGSF4; Tumor suppressor in lung cancer 1SYNCAM1
Molecular Weight
Mass (kDA):
48.509 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q23.3 |
| Sequence: | 11; NC_000011.10 (115169236..115504428, complement) |
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Localized to the basolateral plasma membrane of epithelial cells in gall bladder.
Diseases
- Neoplasms
- Tissue Adhesions
- Malignant Neoplasms
- Malignant Neoplasm Of Lung
- Carcinoma
- Lung Neoplasms
- Non-small Cell Lung Carcinoma
- Cell Transformation, Neoplastic
- Neoplasm Metastasis
- Adenocarcinoma
- Carcinogenesis
- Cell Invasion
Interacting Proteins
- PSMA6
- St8sia2
Pathways
- Cell Adhesion
- Methylation
- Pathogenesis
- Cell-cell Adhesion
- Dna Methylation
- Gene Silencing
- Cell Proliferation
- Cell Cycle
- Spermatogenesis
- Cell Motility
- Cell Migration
- Localization
- Cell Growth
PTMs
- Methylation
- Demethylation
- Cleavage
Research Areas
- Growth and Development
- Neuronal Cell Markers
- Neuroscience
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CADM1
bosterbio.com/bosterbio-gene-info-cards/CADM1
References
PMID: 15893517 by Zhou Y., et al. Nectin-like molecule 1 is a protein 4.1N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane.
PMID: 22438059 by Moiseeva E.P., et al. CADM1 isoforms differentially regulate human mast cell survival and homotypic adhesion.