CAMSAP3 Antibodies

AND CAMSAP3 ELISA kits, CAMSAP3 Proteins

Many biological assays use antibodies to detect CAMSAP3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CAMSAP3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CAMSAP3 antibodies...

We validate the specificity of these antibodies to CAMSAP3 by testing them on tissues known to express CAMSAP3 positively and negatively. Browse below to find the CAMSAP3 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CAMSAP3 Infographic by Boster Bio

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KIAA1543 (CAMSAP3) (NM_001080429) Human Over-expression Lysate

Human

$960
Cat # LS057662
20 µg, 100 µg

CAMSAP3 Overview

Facts about Calmodulin-regulated spectrin-associated protein 3.

CAMSAP3 3D structure. Source: alphafold

Calmodulin-regulated spectrin-associated protein 3 (CAMSAP3)

Key microtubule-organizing protein which specifically binds the minus-end of non-centrosomal microtubules and modulates their dynamics and organization (PubMed:19041755, PubMed:23169647). Acts on free microtubule minus-ends which aren't restricted by microtubule-nucleating proteins or other factors and shields microtubule minus-ends from depolymerization (PubMed:24486153).

Additionally, it also decreases the speed of microtubule polymerization (PubMed:24486153). Required for the biogenesis and the upkeep of zonula adherens by anchoring the minus-end of microtubules into zonula adherens and by recruiting the kinesin KIFC3 to those junctional sites (PubMed:19041755).

Gene Information

Human
Gene Name:	CAMSAP3
Uniprot:	Q9P1Y5
Entrez:	57662

Family

Belongs to:

CAMSAP1 family

Alternative Names

calmodulin regulated spectrin-associated protein family, member 3; calmodulin-regulated spectrin-associated protein 3; KIAA1543; NEZHA; protein Nezha

Molecular Weight

Mass (kDA):
134.75 kDA

Genomic Context


Human

Location:	19p13.2
Sequence:	19; NC_000019.10 (7595863..7618304)

Subcellular Localizations

Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cytoplasm. Scattered in the cytoplasm, associated with the minus-end of microtubules and also detected at the centrosomes (PubMed:19041755, PubMed:24486153, PubMed:27693509). Decorates the minus-end of microtubules by decreasing the rate of tubulin incorporation and remaining bound (PubMed:24486153). Localizes along zonula adherens only at mature cell-cell contacts (PubMed:19041755). In early embryos, accumulates at the microtubule bridges that connect pairs of cells: this structure is present in early embryos, which lack centrosomes (

Pathways

Organelle Assembly

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CAMSAP3

References

PMID: 19041755 by Meng W., et al. Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts.

PMID: 23169647 by Tanaka N., et al. Nezha/CAMSAP3 and CAMSAP2 cooperate in epithelial-specific organization of noncentrosomal microtubules.