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- Table of Contents
CAPG Antibodies
AND CAPG ELISA kits, CAPG Proteins
Many biological assays use antibodies to detect CAPG, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CAPG in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CAPG antibodies...
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CAPG Infographic by Boster Bio
All CAPG Products
Product
Figures
Specificity
Applications
Price
$1249
Cat # PROTP40121
20 µg
Cat # PROTP40121
20 µg
Human
$628
Cat # LS000822
20 µg, 100 µg
Cat # LS000822
20 µg, 100 µg
CAPG Overview
Facts about Macrophage-capping protein.
Macrophage-capping protein (CAPG)
Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function.
May play a role in regulating cytoplasmic and/or atomic structures through potential interactions with actin. May bind DNA.
Gene Information
| Human | |
|---|---|
| Gene Name: | CAPG |
| Uniprot: | P40121 |
| Entrez: | 822 |
Family
| Belongs to: |
|---|
| villin/gelsolin family |
Alternative Names
actin-regulatory protein CAP-G; AFCP; CapG; capping protein (actin filament), gelsolin-like; gelsolin-like capping protein; macrophage capping protein; macrophage-capping protein; MCPActin regulatory protein CAP-G
Molecular Weight
Mass (kDA):
38.499 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p11.2 |
| Sequence: | 2; NC_000002.12 (85394748..85418467, complement) |
Tissue Specificity
Macrophages and macrophage-like cells.
Subcellular Localizations
Nucleus. Cytoplasm. Melanosome. Cell projection, lamellipodium. Cell projection, ruffle. In macrophages, may be predominantly cytoplasmic. Nuclear localization was observed in fibroblasts. In macrophages, present at the membrane-cytoplasm interface. In activated macrophages, concentrated in the ruffles of the leading lamellipodia.
Diseases
- Malignant Neoplasms
- Neoplasms
- Cell Invasion
- Neoplasm Metastasis
- Carcinoma
- Mammary Neoplasms
- Malignant Neoplasm Of Breast
- Neoplasm Invasiveness
- Hypoxia
- Adenocarcinoma
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Lung
- Metastatic Malignant Neoplasm To The Lymph Node
Interacting Proteins
- SIAH1
Pathways
- Cell Motility
- Phagocytosis
- Actin Filament Capping
- Cell Migration
- Pathogenesis
- Transport
- Chemotaxis
- Cell Cycle
- Nuclear Import
- Localization
- Actin Filament Severing
- Nuclear Export
PTMs
- Phosphorylation
- Demethylation
Research Areas
- Cell Biology
- Cellular Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CAPG
bosterbio.com/bosterbio-gene-info-cards/CAPG
References
PMID: 1322908 by Dabiri G.A., et al. Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages.
PMID: 7851883 by Mishra V.S., et al. The human actin-regulatory protein cap G: gene structure and chromosome location.