Cerebellin-1 (CBLN1)

Required for synapse ethics and synaptic plasticity. Throughout cerebellar synapse formation, essential for the fitting and maintenance of pre- and post-synaptic components at parallel fiber-Purkinje cell synapses, the establishment of the correct pattern of climbing fiber-Purkinje cell innervation, and induction of long-term melancholy at parallel fiber-Purkinje cell synapses.

Plays a role as a synaptic organizer that acts bidirectionally on both pre- and post-synaptic components. On the one hand induces accumulation of synaptic vesicles in the pre-synaptic part by binding with NRXN1 and in other hand induces clustering of GRID2 and its associated proteins at the post-synaptic site via institution of GRID2.