Cell cycle and apoptosis regulator protein 2 (CCAR2)

Core component of the DBIRD complicated, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complicated affects local transcript elongation rates and alternative splicing of a huge set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity resulting in increasing levels of p53/TP53 acetylation and p53-mediated apoptosis.

As part of a histone H3- specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress.