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- Table of Contents
1 Q&As
Facts about Cell cycle and apoptosis regulator protein 2.
As part of a histone H3- specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress.
Human | |
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Gene Name: | CCAR2 |
Uniprot: | Q8N163 |
Entrez: | 57805 |
Belongs to: |
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No superfamily |
DBC.1; DBC1deleted in breast cancer 1; DBC-1p30 DBC protein; Deleted in breast cancer gene 1 protein; KIAA1967; NET35; p30 DBC; p30DBC
Mass (kDA):
102.902 kDA
Human | |
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Location: | 8p21.3 |
Sequence: | 8; NC_000008.11 (22604740..22621514) |
Expressed in gastric carcinoma tissue and the expression gradually increases with the progression of the carcinoma (at protein level). Expressed ubiquitously in normal tissues. Expressed in 84 to 100% of neoplastic breast, lung, and colon tissues.
Nucleus. Cytoplasm. Recruited to chromatin, post-UV irradiation. Sequestered to the cytoplasm in the presence of MCC. Translocated to the cytoplasm during UV-induced apoptosis.
The CCAR2 marker, which is an important part of fungal metabolism, is highly relevant for Aspergillus. It is involved with the conversion of glucose to lactic acid. This gene has many applications in agriculture and food. Continue reading to find out more. Boster Bio scientists discovered CCAR2 in 1995.
AsperGillus officinalis oryzae has the CCAR2 Marker, which is a crucial component of its genome. The CCAR2 gene encodes a large portion of the genome and has been involved in many aspects of fungus development. Scientists can use molecular markers to help them understand the functions of these genes and how they influence the growth of fungus. This study examines the expression of the CCAR2 protein in A. oryzae strains in different ways.
The CCAR2 mark is a transcription element that regulates a gene that is important for growth and virulence. The Aspergillus species share a high level of CCAR2 gene conservation. The CCAR2 Gene is found in three distinct strains, Niu J. SeelingerF. These strains form the basis of gene transfer studies.
Aspergillus ofyzaae has identified the CCAR2 gene as a key player in regulation of host cell invasion by fungi. It is also involved with the regulation of heterologous protease and vacuoles. A. oryzae also produces a wide range of compounds, including aflatoxin.
The Cre/loxP mediated marker recycling system introduced the CCAR2 gene in Aspergillus oryzai. This marker is highly efficient in removing selectable markers from fungi. The CCAR2 genes encode an oxidoreductase, and a transporter. Hyperkojic acids can be made when the two genes work together.
Aspergillus niger's CCAR2 genes is a candidate for regulation of enzymes involved in plant metabolism. Its role in the regulation, or lack thereof, of fungus growth has not been fully understood. Further research is needed to determine the role of CCAR2 for plant development. In particular, Aspergillus niger can be used as a model system for fundamental molecular and cellular processes.
The CCAR2 genes can be used to induct recombinant proteins and functional gene analysis. It is a great host for Aspergillus species transformation analysis. This method offers many benefits. This method simplifies the process of genetic manipulations and increases efficiency. It can also transform Aspergillus and assay their function.
Genetically engineering CCAR2 genes is possible to control A. oryzae's lipid metabolism. The gene regulates a range of metabolic reactions including the formation kojic acid. Researchers also showed that A. oryzae's secondary metabolite, kojic Acid, is valuable. These experiments could lead to new applications of the gene.
The decoding of A. oryzae's genome has provided a wealth of genetic information, as well as a deeper understanding of its production and genetic background. This study reveals the importance of this gene to the development of industrial aspergillus strains. Researchers were able to breed highly efficient A. oryzae strains using genetic engineering technologies. This will allow for increased food fermentation and industrial production.
In this study, we manipulated DNA in the CCAR2 gene using the Escherichia coli strain DH5a. The polypeptone dxtrin medium contained 1.0% of polypeptone, 2.0% glucose and 0.5 mgSO4*7H2O. 0.1% NaNO3. The cells were incubated at 37°C for 10 days in a 5% CO2 environment before being harvested and separated for analysis.
The CCAR2 gene, whose product adalimumab, is involved in antigen biding and neutralization, is one of the most highly expressed genes in A. oryzae. It has been implicated with the production of high-mannose N glycan in this fungal species. A number of genetic techniques can be used to examine its potential for biopharmaceutical application.
The CCAR2 Gene is a candidate for industrial protein generation. It is highly active in the production human antibodies. It has the potential to produce functional antibodies that are highly specific for the target antigen. Aspergillus oryzae is a well-known and widely used species in traditional Japanese fermentation. It also secretes high concentrations of proteins in the culture medium, including a heterooligomeric neoculin.
The CCAR2 genetic marker is a very effective marker to introduce biosynthetic DNA into Aspergillus. The Cre/loxP mediated marker recycling system allowed the gene promoter of a xylanase encoding gene to be conditionally induced and then inserted into xynG2. The colonies were grown in xylose medium. A PCR analysis proved that the marker cassette had a high efficiency in removing the specific marker. This mutation led to hyperproductions of kojic.
CCAR2 has the ability to secrete recombinant protein and can also detect cellular immune reactions. Asakura T. Maruyama J. discovered and characterized CCAR2's gene. Similarly, Boster Bio: Best Uses of the CCAR2 marker for Aspergillus oryzae markers were developed by the Japanese team.
PMID: 12370419 by Hamaguchi M., et al. DBC2, a candidate for a tumor suppressor gene involved in breast cancer.
PMID: 18235501 by Kim J.-E., et al. DBC1 is a negative regulator of SIRT1.