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- Table of Contents
Facts about C-C motif chemokine 25.
Binds to CCR9. Isoform 2 is an antagonist of isoform 1.
Human | |
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Gene Name: | CCL25 |
Uniprot: | O15444 |
Entrez: | 6370 |
Belongs to: |
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intercrine beta (chemokine CC) family |
C-C motif chemokine 25; CCL25; chemokine (C-C motif) ligand 25; Chemokine TECK; Ck beta-15; Ckb15; SCYA25TECKvar; small inducible cytokine subfamily A (Cys-Cys), member 25; Small-inducible cytokine A25; TECK; TECKMGC150327; thymus expressed chemokine; Thymus-expressed chemokine
Mass (kDA):
16.609 kDA
Human | |
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Location: | 19p13.2 |
Sequence: | 19; NC_000019.10 (8052318..8062663) |
Specifically expressed by thymic dendritic cells. High levels in thymus and small intestine.
Secreted.
You can optimize your experiment by adjusting the flow procedure. There are many options. From the methods available to the products that can be ordered, there are many. For more information, visit the BosterBio optimization guide. There are many tips and tricks that will help you optimize your experiments. Moreover, you can read the customer testimonials to see if the product is right for your research.
The CCL25 marker can be used in many immunological studies. It is a versatile and useful protein that can be used for many purposes, including the treatment or inflammation. It has been used in numerous clinical trials for many disorders, including inflammation bowel disease. There are some limitations. This molecule is not approved for use in the manufacture of drugs. However, it is currently being studied in clinical trials.
The CCL25 marker is a highly potent pro-inflammatory cytokine and it can lead to massive local inflammation and tissue degradation. Enzymatic activity degrades the CCL25 & PLGA protein, and particle supernatants are richer in CCL25 and undegraded particles. In addition, degraded particles did not enhance the migration of inflammatory cells, and did not increase HLA-DR expression.
The half-life of CCL25 protein is very long. CCL25 can be activated by inflammatory processes when it reaches 500 nM. CCL25 recruits leukocytes, and induces cytokine release. CCL25, therefore, is an important cytokine to research inflammation. CCL25 levels in supernatants are lower than 100nM.
In addition, this chemokine is involved in the development of the adaptive immune system. It is implicated in the dysfunctional immune system processes of inflammatory-bowel disease and arthritis. There are also concerns about the CCL25 marker's ability to induce a significant inflammatory response. PLGA has acidic qualities, so PLGA could cause an undesirable inflammatory reaction.
The CC family contains the small cytokine (CC) gene. Cytokines are secreted substances that have chemotactic properties for dendritic cell and thymocytes. However, they do not exhibit any activity for lymphocytes in peripheral blood. This gene encodes an innocuous cytokine, which binds only to the CCR9 chemokine receptor. Multiple transcript variants can be created by alternative splicing.
CCL25 stimulation of PBMCs results in strong secretion proinflammatory mediators. However, CCL25 stimulated PBMCs at ten nanometers (nM) and one hundred nanograms (mM) only moderately enhanced secretion. Only IL-8 showed a statistically meaningful increase in secretion after low CCL25 levels. Moreover, secretion fell after five days stimulation.
The CC chemokines mRNA is widely expressed in the thymus and small intestine. However, only a few cells secrete the chemokine. CCL25 gene expression is high in small intestinal epithelium and murine thymus. It's also expressed by pro-T cells, MHCII+DCs, and the murine and small intestine thymus. CCR9+ T cell lines also express the a4b7 Integrin, which indicates their contribution to mucosal immunity.
However, sudden release of large amounts of CCL25 might not be the best therapy for OA. It could even be counterproductive. It could also increase inflammation and worsen the symptoms of OA. This is why it is important to conduct these studies in order to find potential treatments for OA. This marker should be investigated further if it is helpful. What is the best treatment of OA?
CCR9 and CCL25 products interact with each other and are known to play a role in intestinal homing. CCR9 is expressed in lymphocytes from the small intestinale. CCR9-negative lymphocytes from other tissues are generally negative for CCR9. These molecules attract some intestinal memory cells, but they don't attract systemic ones. Inamoto has collaborated with colleagues to study the role played by the CCR9 genetic polymorphism during GVHD.
CCR9 mRNA is highly expressed in lymphocytes following fetal development. The development of the ovine thyroid is influenced by CCL25/CCR9. CCR9-dependent mRNA expression could be useful for predicting the development of cancer. It may also be useful in understanding the roles of CCL25/CCR9 in ovarian carcinoma. The treatment of cancer can be negatively affected by inflamatory reactions.
CCR9/CCL25 increases AKT signaling within early-stage colorectal tumor cells. To enrich the splenocytes of ASC with rat antithy-1.2 and anti-Cy3 antibodies, we used rats. This method showed that CCR9+ early-stage CRC cells chemotax towards the CCL25-labeled solution.
The CCR9/CCL25 axis promotes colon CCIC growth and inhibits invasion. Moreover, CCICs are not expressed in extra-gastrointestinal sites. These data show that CCR9 signaling and CCL25 signaling are both the most suitable in vivo experimental systems for monitoring CRC progression and invasion. The colon tumor formation process is influenced by the NOTCH/CCL25 axis.
It's easy to gather testimonials from customers for the CCL25 marker if you know where to find them. Whether your customers are longtime clients or recent newcomers, it's important to ensure the testimonials are authentic and relatable. To ensure testimonials are credible, ask your customers to give you their name, company name (title), and any other pertinent demographic information. You can also ask them for a sample of their CCL25 results and see if you can use this information to improve your marketing efforts.
A number of reasons make it important to include testimonials from customers, including SEO and merchandising. First, testimonials can increase the visibility of your website on search engines. You can increase site traffic up to 45% simply by including testimonials. Customer testimonials are rich in long-tail keywords, which is another reason to include them on your site. Customers testimonials can be shared via social media, which will boost SEO efforts.
You can also request testimonials from customers by email or calling. This will ensure that you capture their words exactly. By using the exact words, you'll ensure that your testimonials are more authentic. Before using their testimonials, it is essential to obtain permission from your customers. This is because recording their conversations may be illegal in some states. Before using testimonials from them in marketing materials, you will need to get their permission.
PMID: 9285413 by Vicari A.P., et al. TECK: a novel CC chemokine specifically expressed by thymic dendritic cells and potentially involved in T cell development.
PMID: 10229797 by Zaballos A., et al. Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK.