Centromere protein T (CENPT)

The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complicated and can be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome- associated complex that binds specifically to histone H3- containing nucleosomes in the centromere, instead of nucleosomes containing CENPA.

Part of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function.