Cocaine esterase Antibodies

AND CES2 ELISA kits, Cocaine esterase Proteins

Many biological assays use antibodies to detect Cocaine esterase, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cocaine esterase in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cocaine esterase antibodies...

We validate the specificity of these antibodies to Cocaine esterase by testing them on tissues known to express CES2 positively and negatively. Browse below to find the CES2 antibody that suites your experiment. We have 6 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for Cocaine esterase? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the CES2 IHC Guide

CES2 Infographic by Boster Bio

All CES2 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Human CES2 ELISA Kit PicoKine®

Human

ELISA

$499
Cat # EK1814
96 wells/kit, with removable strips.

Anti-CES2 Antibody (Center)

Human

Flow Cytometry, IHC-P, WB

$299
Cat # A02868-1
80 µl

Anti-CES2 Antibody Picoband®

Western blot analysis of CES2 using anti-CES2 antibody (A02868-2)

IHC analysis of CES2 using anti-CES2 antibody (A02868-2)

IF analysis of CES2 using anti-CES2 antibody (A02868-2)

Human, Mouse

ELISA, IF, IHC, WB

$370
Cat # A02868-2
100 μg/vial

CES2 (NM_003869) Human Over-expression Lysate

CES2 Human Over-expression Lysates NM_003869

Human

$628
Cat # LS008824
20 µg, 100 µg

CES2 (NM_198061) Human Recombinant Protein

Coomassie blue staining of purified CES2 protein

$1062
Cat # PROTO00748
20 µg

Mouse Ces2e Recombinant Protein

3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain

Enzyme Activity, SDS-PAGE

$250
Cat # PROTQ8BK48
Starting from 10ug

CES2 Overview

Facts about Cocaine esterase.

CES2 3D structure. Source: alphafold

Cocaine esterase (CES2)

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443). Shows high catalytic efficiency for hydrolysis of cocaine, 4- methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (PubMed:9169443).

Hydrolyzes aspirin, substrates with big alcohol group and little acyl group and endogenous lipids like triacylglycerol (PubMed:28677105). .

Gene Information

Human
Gene Name:	CES2
Uniprot:	O00748
Entrez:	8824

Family

Belongs to:

type-B carboxylesterase/lipase family

Alternative Names

carboxylesterase 2 (intestine, liver); Carboxylesterase 2; carboxylesterase 2EC 3.1.1.1; CE-2; CE-2PCE-2; CES2; CES2A1; EC 3.1.1; EC 3.1.1.84; hCE-2; iCE; intestinal carboxylesterase; liver carboxylesterase-2; PCE-2

Molecular Weight

Mass (kDA):
61.807 kDA

Genomic Context


Human

Location:	16q22.1
Sequence:	16; NC_000016.10 (66934471..66945096)

Tissue Specificity

Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum.

Subcellular Localizations

Endoplasmic reticulum lumen.

Diseases

Malignant Neoplasms
Neoplasms
Colorectal Cancer
Colorectal Neoplasms
Diarrhea
Malignant Tumor Of Colon
Colonic Neoplasms
Hepatotoxicity
Lymphoma
Mammary Neoplasms
Dysequilibrium Syndrome
Adenocarcinoma
Liver Carcinoma

Hypertrophy
Inflammation
Atherosclerosis
Palmar-plantar Erythrodysesthesia Syndrome
Carcinoma
Ovarian Neoplasm
Influenza

Pathways

Transport
Intestinal Absorption
Cell Death
Cell Growth
Secretion
Cell Proliferation
Circadian Rhythm
Cytokine Secretion
Conjugation
Localization
Rna Capping
Nuclear Division
Response To Irinotecan

Reverse Transcription
Sensitization
Translation
Sperm Motility
Reverse Cholesterol Transport
Cholesterol Transport
Excretion

PTMs

Phosphorylation
Hydroxylation
Glycosylation

Cleavage
Oxidation
Acylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CES2

References

PMID: 9144407 by Schwer H., et al. Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver.

PMID: 9169443 by Pindel E.V., et al. Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin.