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Cofilin-2 Antibodies
AND CFL2 ELISA kits, Cofilin-2 Proteins
Many biological assays use antibodies to detect Cofilin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cofilin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cofilin-2 antibodies...
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CFL2 Infographic by Boster Bio
All CFL2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # RP1107
100 μg/vial
Cat # RP1107
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M04773
100 μg/vial
Cat # M04773
100 μg/vial
CFL2 Overview
Facts about Cofilin-2.
Cofilin-2 (CFL2)
Controls reversibly actin polymerization and depolymerization in a pH-sensitive method. Its F-actin depolymerization activity is regulated by association with CSPR3 (PubMed:19752190).
It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It's the major component of intranuclear and cytoplasmic actin rods.
Gene Information
| Human | |
|---|---|
| Gene Name: | CFL2 |
| Uniprot: | Q9Y281 |
| Entrez: | 1073 |
Family
| Belongs to: |
|---|
| actin-binding proteins ADF family |
Alternative Names
cofilin 2 (muscle); Cofilin, muscle isoform; cofilin-2; NEM7
Molecular Weight
Mass (kDA):
18.737 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q13.1 |
| Sequence: | 14; NC_000014.9 (34709113..34714823, complement) |
Tissue Specificity
Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues.
Subcellular Localizations
Nucleus matrix. Cytoplasm, cytoskeleton. Colocalizes with CSPR3 in the Z line of sarcomeres.
Diseases
- Myopathy
- Myopathies, Nemaline
- Weakness
- Congenital Myopathy (disorder)
- Neoplasms
- Muscle Weakness
- Malignant Neoplasms
- Congenital Fiber Type Disproportion
- Arthrogryposis
- Distal Arthrogryposis Syndrome
- Muscular Dystrophy
- Distal Muscular Dystrophies
Interacting Proteins
- ACTB
- ACTG1
- CSRP3
Pathways
- Pathogenesis
- Cell Adhesion
- Neural Tube Closure
- Cell Proliferation
- Cell Migration
- Neural Crest Cell Migration
- Dna Methylation
- Dna Repair
- Muscle Contraction
- Smooth Muscle Hypertrophy
- Tube Morphogenesis
- Actin Filament Depolymerization
- Localization
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CFL2
bosterbio.com/bosterbio-gene-info-cards/CFL2
References
PMID: 11422377 by Thirion C., et al. Characterization of human muscle type cofilin (CFL2) in normal and regenerating muscle.
PMID: 19752190 by Papalouka V., et al. Muscle LIM protein interacts with cofilin 2 and regulates F-actin dynamics in cardiac and skeletal muscle.