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- Table of Contents
Cofilin-2 Antibodies
AND CFL2 ELISA kits, Cofilin-2 Proteins
Many biological assays use antibodies to detect Cofilin-2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cofilin-2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cofilin-2 antibodies...
Designing a Western blot for Cofilin-2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CFL2 Western Blot GuideCFL2 Infographic by Boster Bio
All CFL2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$370
Cat # M04777
100 μg/vial
Cat # M04777
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M04773
100 μg/vial
Cat # M04773
100 μg/vial
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M05022-2
100 μg/vial
Cat # M05022-2
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M05020-2
100 μg/vial
Cat # M05020-2
100 μg/vial
Human
IF, IHC, ICC, WB
$370
Cat # M04803-1
100 μg/vial
Cat # M04803-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M05020-1
100 μg/vial
Cat # M05020-1
100 μg/vial
Human
Flow Cytometry, IHC, WB
$370
Cat # M04796-2
100 μg/vial
Cat # M04796-2
100 μg/vial
Human, Mouse, Rat
IHC, WB
$370
Cat # M04814-1
100 μg/vial
Cat # M04814-1
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # RP1107
100 μg/vial
Cat # RP1107
100 μg/vial
Human, Mouse
Flow Cytometry, WB
$370
Cat # M04933-2
100 μg/vial
Cat # M04933-2
100 μg/vial
CFL2 Overview
Facts about Cofilin-2.
Cofilin-2 (CFL2)
Controls reversibly actin polymerization and depolymerization in a pH-sensitive method. Its F-actin depolymerization activity is regulated by association with CSPR3 (PubMed:19752190).
It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It's the major component of intranuclear and cytoplasmic actin rods.
Gene Information
| Human | |
|---|---|
| Gene Name: | CFL2 |
| Uniprot: | Q9Y281 |
| Entrez: | 1073 |
Family
| Belongs to: |
|---|
| actin-binding proteins ADF family |
Alternative Names
cofilin 2 (muscle); Cofilin, muscle isoform; cofilin-2; NEM7
Molecular Weight
Mass (kDA):
18.737 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q13.1 |
| Sequence: | 14; NC_000014.9 (34709113..34714823, complement) |
Tissue Specificity
Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues.
Subcellular Localizations
Nucleus matrix. Cytoplasm, cytoskeleton. Colocalizes with CSPR3 in the Z line of sarcomeres.
Diseases
- Myopathy
- Myopathies, Nemaline
- Weakness
- Congenital Myopathy (disorder)
- Neoplasms
- Muscle Weakness
- Malignant Neoplasms
- Congenital Fiber Type Disproportion
- Arthrogryposis
- Distal Arthrogryposis Syndrome
- Muscular Dystrophy
- Distal Muscular Dystrophies
Interacting Proteins
- ACTB
- ACTG1
- CSRP3
Pathways
- Pathogenesis
- Cell Adhesion
- Neural Tube Closure
- Cell Proliferation
- Cell Migration
- Neural Crest Cell Migration
- Dna Methylation
- Dna Repair
- Muscle Contraction
- Smooth Muscle Hypertrophy
- Tube Morphogenesis
- Actin Filament Depolymerization
- Localization
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CFL2
bosterbio.com/bosterbio-gene-info-cards/CFL2
References
PMID: 11422377 by Thirion C., et al. Characterization of human muscle type cofilin (CFL2) in normal and regenerating muscle.
PMID: 19752190 by Papalouka V., et al. Muscle LIM protein interacts with cofilin 2 and regulates F-actin dynamics in cardiac and skeletal muscle.