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CLCA2 Antibodies
AND CLCA2 ELISA kits, CLCA2 Proteins
Many biological assays use antibodies to detect CLCA2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CLCA2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CLCA2 antibodies...
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CLCA2 Overview
Facts about Calcium-activated chloride channel regulator 2.
Calcium-activated chloride channel regulator 2 (CLCA2)
Plays a role in modulating chloride present across the plasma membrane in a calcium-dependent fashion, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia.
May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion at the beginning stages of lung metastasis through the binding to ITGB4.
Gene Information
| Human | |
|---|---|
| Gene Name: | CLCA2 |
| Uniprot: | Q9UQC9 |
| Entrez: | 9635 |
Family
| Belongs to: |
|---|
| CLCR family |
Alternative Names
CACC; CACC3; CaCC-3; Calcium-activated chloride channel family member 2; Calcium-activated chloride channel protein 3; calcium-activated chloride channel regulator 2; calcium-activated chloride channel-2; chloride channel accessory 2; chloride channel regulator 2; chloride channel, calcium activated, family member 2; CLCA family member 2, chloride channel regulator; CLCA2; CLCRG2; FLJ97885; hCaCC-3; hCLCA2
Molecular Weight
Mass (kDA):
103.941 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p22.3 |
| Sequence: | 1; NC_000001.11 (86424144..86456553) |
Tissue Specificity
Expressed in cornea, skin, vagina, esophagus, and larynx (at protein level). Expressed in trachea and mammary gland. Weakly expressed in testis and kidney. Highly expressed in corneal epithelium, colon and trachea. Moderately expressed in brain, urogenital organs, bladder, uterus and prostate. Highly expressed in tissues containing stratified epithelium including cornea, esophagus, larynx, skin and vagina than those tissues which contain only epithelial monolayers. Expressed in normal breast epithelium but not in breast cancer. Highly expressed during epithelial stratification. Expressed in endothelial cells of lung. Expressed selectively in endothelia of small pulmonary arteries, arterioles, and subpleural and interlobular venules.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein. Basal cell membrane; Single-pass type I membrane protein. Cell junction.; [Calcium-activated chloride channel regulator 2, 109 kDa form]: Secreted. Remains associated to the 35 kDa form until an unidentified event triggers the release.
Diseases
- Neoplasms
- Malignant Neoplasms
- Mammary Neoplasms
- Malignant Neoplasm Of Breast
- Neoplasm Metastasis
- Tissue Adhesions
- Malignant Paraganglionic Neoplasm
- Tumor Progression
- Carcinoma
- Cell Invasion
- Fibrosis
- Colorectal Neoplasms
Pathways
- Transport
- Cell Adhesion
- Cell Proliferation
- Secretion
- Cell Cycle
- Cell Cycle Arrest
- Localization
- Senescence
- Pathogenesis
- Gene Silencing
- Cellular Senescence
- Immune Response
- Lung Development
PTMs
- Cleavage
Research Areas
- Breast Cancer
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLCA2
bosterbio.com/bosterbio-gene-info-cards/CLCA2
References
PMID: 10362588 by Gruber A.D., et al. Molecular cloning and transmembrane structure of hCLCA2 from human lung, trachea, and mammary gland.
PMID: 10437792 by Agnel M., et al. Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea.