CLCN5 Antibodies

AND CLCN5 ELISA kits, CLCN5 Proteins

Many biological assays use antibodies to detect CLCN5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CLCN5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CLCN5 antibodies...

We validate the specificity of these antibodies to CLCN5 by testing them on tissues known to express CLCN5 positively and negatively. Browse below to find the CLCN5 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for CLCN5? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the CLCN5 Western Blot Guide

CLCN5 Infographic by Boster Bio

All CLCN5 Products

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Product

Figures

Specificity

Applications

Price

Chloride Channel 5 (CLCN5) (NM_000084) Human Over-expression Lysate

Human

$960
Cat # LS001184
20 µg, 100 µg

Anti-ClC-5/CLCN5 Antibody Picoband®

Western blot analysis of ClC-5/CLCN5 using anti-ClC-5/CLCN5 antibody (A02286-2)

Human, Mouse, Rat

ELISA, WB

$370
Cat # A02286-2
100 μg/vial

Anti-CLCN5 Antibody

Western blot analysis of extracts of various cell lines, using CLCN5 antibody at 1:1000 dilution

Human, Mouse

$405
Cat # A02286
100ul

Anti-CLCN5 Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A02286-1
100ul

CLCN5 Overview

Facts about H(+)/Cl(-) exchange transporter 5.

CLCN5 3D structure. Source: alphafold

H(+)/Cl(-) exchange transporter 5 (CLCN5)

Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons.

Important for normal acidification of the endosome lumen. May play an essential role in renal tubular function.

Gene Information

Human
Gene Name:	CLCN5
Uniprot:	P51795
Entrez:	1184

Family

Belongs to:

chloride channel (TC 2.A.49) family

Alternative Names

chloride channel 5; Chloride channel protein 5; Chloride transporter ClC-5; CLC5; clC-5; CLCK2NPHL2; DENTSNPHL1; H(+)/Cl(-) exchange transporter 5; hCIC-K2; hClC-K2; nephrolithiasis 1 (X-linked); nephrolithiasis 2, X-linked; XLRH; XRN

Molecular Weight

Mass (kDA):
83.147 kDA

Genomic Context


Human

Location:	Xp11.23
Sequence:	X; NC_000023.11 (49922596..50099235)

Tissue Specificity

Kidney. Moderately expressed in aortic vascular smooth muscle and endothelial cells, and at a slightly higher level in the coronary vascular smooth muscle.

Subcellular Localizations

Golgi apparatus membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Diseases

Dent's Disease
Proteinuria Of Undiagnosed Cause
Hypercalciuria
Nephrocalcinosis
Nephrolithiasis
Kidney Diseases
Kidney Failure
Kidney Calculi
Rickets
Renal Tubular Disorder
Fanconi Syndrome
Genetic Diseases, X-linked
Hypophosphatemic Rickets

Hypophosphatemia
Oculocerebrorenal Syndrome
Renal Insufficiency
Phosphate Diabetes
Aminoaciduria
Acidosis
Familial Hypophosphatemia

Interacting Proteins

KIF3B

Pathways

Endocytosis
Excretion
Transport
Pathogenesis
Translation
Receptor-mediated Endocytosis
Reverse Transcription
Cell Proliferation
Glycosylation
Localization
Glomerular Filtration
Secretion
Cell Adhesion

Gene Silencing
Osteoblast Differentiation
Cell Cycle Phase
Immune Response
Regulation Of Gene Expression
Chondrocyte Differentiation
Intestinal Absorption

PTMs

Glycosylation

Biotinylation

Hydroxylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CLCN5

References

PMID: 8575751 by Fisher S.E., et al. Cloning and characterization of CLCN5, the human kidney chloride channel gene implicated in Dent disease (an X-linked hereditary nephrolithiasis).

PMID: 7874126 by Fisher S., et al. Isolation and partial characterization of a chloride channel gene which is expressed in kidney and is a candidate for Dent's disease (an X-linked hereditary nephrolithiasis).