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- Table of Contents
Facts about Calsyntenin-3.
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Human | |
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Gene Name: | CLSTN3 |
Uniprot: | Q9BQT9 |
Entrez: | 9746 |
Belongs to: |
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No superfamily |
alcadein beta; alcadein-beta; alcbeta; Alc-beta; cadherin-related family member 14; calsyntenin 3; Calsyntenin3; Calsyntenin-3; CDHR14; CLSTN3; CS3; CSTN3; KIAA0726alcbeta; MGC131797; MGC138488
Mass (kDA):
106.098 kDA
Human | |
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Location: | 12p13.31 |
Sequence: | 12; NC_000012.12 (7130371..7158945) |
According to PubMed:12498782, expressed predominantly in the brain and in kidney. Low levels in heart, skeletal muscle, liver, placenta, pancreas and lung. According to PubMed:12972431, predominant expression in brain, and only marginal in kidney. In brain, present throughout all cortical layers, highest levels in GABAergic neurons (based on morphology and distribution pattern).
Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane. Golgi apparatus membrane. Cell junction, synapse, postsynapse. Cell projection, dendrite. Most prominent in the postsynaptic specializations of asymmetric (type I) synapses with both axodendritic and axospinous localization.
PMID: 12498782 by Hintsch G., et al. The calsyntenins - a family of postsynaptic membrane proteins with distinct neuronal expression patterns.
PMID: 15037614 by Araki Y., et al. Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation.