Cyclic nucleotide-gated cation channel alpha-4 (CNGA4)

Second messenger, cAMP, causes the opening of cation- selective cyclic nucleotide-gated (CNG) channels and depolarization of the neuron (olfactory sensory neurons, OSNs). CNGA4 is the modulatory subunit of the channel which is known to play a central role in the transduction of odorant signals and subsequent adaptation.

By accelerating the calcium-mediated negative feedback in olfactory signaling it allows rapid adaptation to odor stimulation and extends its range of odor detection (By similarity). .