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- Table of Contents
Facts about COP9 signalosome complex subunit 8.
The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
Human | |
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Gene Name: | COPS8 |
Uniprot: | Q99627 |
Entrez: | 10920 |
Belongs to: |
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CSN8 family |
COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis); COP9 homolog; COP9 signalosome complex subunit 8; COP9; CSN8JAB1-containing signalosome subunit 8; hCOP9; MGC1297; MMMEP; SGN8MGC43256; Signalosome subunit 8
Mass (kDA):
23.226 kDA
Human | |
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Location: | 2q37.3 |
Sequence: | 2; NC_000002.12 (237085441..237100474) |
Cytoplasm. Nucleus.
There are many things to consider when setting up a flow protocol. It is important you understand your objectives and know how to get there. If you are unsure about what to do, you can find out more with Boster Bio's optimization guides. There are many questions you may have about how to set up the COPS8 marker and how to design your flow process. You can also find out how to price your products.
COPS8 is a gene expressed on cells within the body. COPS8 may be used to detect cancer by being a common marker in blood cell cells. Researchers are interested in using COPS8 in cancer research, but the best way to find out how to use it is to design experiments that target this gene. Here are some helpful tips and tricks. Here are some popular uses for COPS8 in cancer research.
The COPS8 gene is located at chromosome 2q37.3. It encodes the CSN8-subunit, which plays a crucial role in animal development. A variety of cancers are caused by members from the CSN. Xiao et al. We examined the expression levels COPS8 and found CSN5 to be up-regulated, while CSN6 is rarely expressed in lung cancer.
In human melanoma, COPS8 promotes EMT and cell migration. COPS8 can also increase vimentin and Ecadherin expression, aswell as snail protein expression. It does not impact melanin. These are two very different cancers, which are related to each other. Although COPS8 expression is higher in melanoma cells it is not clear if it plays a role in EMT regulation.
The results of this study suggest that COPS8 expression is associated with DNA repair and hypoxia responses. In IHC assay, COPS8 was not detected in HNSCC tissue. The detection might have been affected by the low sensitivity of the primary antibody. Future studies should therefore focus on the function and role of COPS8 at HNSCC. The results of this study are encouraging. But further studies are necessary to determine whether COPS8 can detect other cancer markers, as well.
COPS8 expression in cutaneous melanomas cells was altered. Transfections with siCOPS8 or siCON in M21 cells increased COPS8 production. Transfection of A375 cells expressing pcDNA3.1–COPS8 resulted in increased expression of COPS8 in both tumors as well as healthy control cells. These findings indicate that COPS8 may have a role in the progression of cutaneous melanoma.
PMID: 7634324 by Chamovitz D.A., et al. The novel components of the Arabidopsis light signaling pathway may define a group of general developmental regulators shared by both animal and plant kingdoms.
PMID: 9535219 by Seeger M., et al. A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits.