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Product Info Summary
| SKU: | A07142 |
|---|---|
| Size: | 0.1 mg |
| Reactive Species: | Human, Mouse, Rat |
| Host: | Rabbit |
| Application: | ELISA, WB |
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Product info
Product Name
Anti-CSN8 COPS8 Antibody
SKU/Catalog Number
A07142
Size
0.1 mg
Form
Liquid
Description
Boster Bio Anti-CSN8 COPS8 Antibody (Catalog # A07142). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.
Storage & Handling
CSN8 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Cite This Product
Anti-CSN8 COPS8 Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A07142)
Host
Rabbit
Contents
CSN8 Antibody is supplied in PBS containing 0.02% sodium azide.
Clonality
Polyclonal
Isotype
IgG
Immunogen
CSN8 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of the human CSN8. The immunogen is located within the last 50 amino acids of CSN8.
Reactive Species
A07142 is reactive to COPS8 in Human, Mouse, Rat
Observed Molecular Weight
68 kDa
Calculated molecular weight
23.2 kDa
Background of COPS8
The COP9 signalosome (CSN) is an evolutionarily conserved protein complex of the eight subunits that interacts with deubiquitinating enzymes and protein kinases and is highly homologous to the lid sub-complex of 26S proteasome. The CSN complex is an essential regulator of the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF-comlpexes such as SCF, CSA or DDB2. It is also involved in phosphorylation of p53, c-jun/JUN, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN8 encodes the smallest and the least conserved but first identified subunit of CSN. Recent studies show CSN8 is essential for Drosophila development and is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence.
Antibody Validation
Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.
Application & Images
Applications
A07142 is guaranteed for ELISA, WB Boster Guarantee
Assay Dilutions Recommendation
The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.
CSN8 antibody can be used for detection of CSN8 by Western blot at 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.
Validation Images & Assay Conditions
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Western blot analysis of CSN8 in Human liver lysate with CSN8 antibody at 2 μg/mL.
Specific Publications For Anti-CSN8 COPS8 Antibody (A07142)
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