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- Table of Contents
CRTC3 Antibodies
AND CRTC3 ELISA kits, CRTC3 Proteins
Many biological assays use antibodies to detect CRTC3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CRTC3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CRTC3 antibodies...
Designing a Western blot for CRTC3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CRTC3 Western Blot GuideDesigning an IHC experiment for CRTC3? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the CRTC3 IHC GuideCRTC3 Infographic by Boster Bio
All CRTC3 Products
Product
Figures
Specificity
Applications
Price
Human, Monkey
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A04568-2
100 μg/vial
Cat # A04568-2
100 μg/vial
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M04568
100 μl/vial
Cat # M04568
100 μl/vial
CRTC3 Overview
Facts about CREB-regulated transcription coactivator 3.
CREB-regulated transcription coactivator 3 (CRTC3)
Transcriptional coactivator for CREB1 which activates transcription via both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1'Ser-133' phosphorylation.
Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR.
Gene Information
| Human | |
|---|---|
| Gene Name: | CRTC3 |
| Uniprot: | Q6UUV7 |
| Entrez: | 64784 |
Family
| Belongs to: |
|---|
| TORC family |
Alternative Names
CREB regulated transcription coactivator 3; CRTC3; FLJ21868; TORC3; TORC-3; TORC3CREB-regulated transcription coactivator 3; Transducer of CREB protein 3; transducer of regulated cAMP response element-binding protein (CREB) 3; Transducer of regulated cAMP response element-binding protein 3; transducer of regulated CREB protein 3
Molecular Weight
Mass (kDA):
66.959 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 15q26.1 |
| Sequence: | 15; NC_000015.10 (90529915..90645345) |
Tissue Specificity
Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach.
Subcellular Localizations
Nucleus. Cytoplasm. Appears to be mainly nuclear (PubMed:15454081). Translocates to the nucleus following adenylyl cyclase or MAP kinase activation (PubMed:30611118).
Diseases
- Mucoepidermoid Carcinoma
- Leukemia, T-cell
- Carcinoma
- Neoplasms
- Leukemia
- Salivary Gland Neoplasms
- Neoplasm Metastasis
- Salivary Gland Diseases
- Salivary Gland Carcinoma
- Oncogene Fusion
- Autoimmune Diseases
- Insulin Resistance
- Malignant Neoplasms
Pathways
- Cellular Respiration
- Reverse Transcription
- Viral Transcription
- Fatty Acid Oxidation
- Rna Interference
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CRTC3
bosterbio.com/bosterbio-gene-info-cards/CRTC3
References
PMID: 14506290 by Iourgenko V., et al. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells.
PMID: 12693554 by Jikuya H., et al. Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones.