CREB-regulated transcription coactivator 3 (CRTC3)

Transcriptional coactivator for CREB1 which activates transcription via both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1'Ser-133' phosphorylation.

Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR.