CTBP2 Antibodies

C-terminal-binding protein 2 (CTBP2)

Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity).

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Gene Information

Human
Gene Name:	CTBP2
Uniprot:	P56545
Entrez:	1488

Family

Belongs to:
D-isomer specific 2-hydroxyacid dehydrogenase family

Alternative Names

CtBP2; C-terminal binding protein 2, 10ribeye; C-terminal-binding protein 2

Molecular Weight

Mass (kDA):
48.945 kDA

Genomic Context

Human
Location:	10q26.13
Sequence:	10; NC_000010.11 (124984317..125161039, complement)

Tissue Specificity

Ubiquitous. Highest levels in heart, skeletal muscle, and pancreas.

Subcellular Localizations

Nucleus. Cell junction, synapse.

Diseases

• Neoplasms
• Malignant Neoplasms
• Nervousness
• Neoplasm Metastasis
• Carcinoma
• Cell Invasion
• Cell Transformation, Neoplastic
• Complete Hearing Loss
• Malignant Tumor Of Colon
• Mammary Neoplasms
• Blind Vision
• Dystrophy

• Night Blindness
• Crest Syndrome
• Leukemia
• Sensorineural Hearing Loss (disorder)
• Congenital Stationary Night Blindness
• Malnutrition
• Hypoxia

Interacting Proteins

• BCAS3
• BCL3
• CACNB3
• CCNH
• FLI1

• FOXP2
• FUNDC1
• HIC1
• HOXB5
• IKZF1

• IKZF2
• LCOR
• NOL4L
• PLCB1
• PPP1R15A

• PROX1
• RAI2
• RIMBP3
• SOX13
• TGIF1

• TSHZ3
• ZBTB18
• ZBTB42
• ZNF750

Pathways

• Localization
• Exocytosis
• Cell Proliferation
• Synaptic Transmission
• Cell Migration
• Cell Differentiation
• Transport
• Cell Cycle
• Nuclear Import
• Mitosis
• Vesicle Fusion
• Synaptic Vesicle Fusion
• Rna Interference

• Cell Adhesion
• Gene Silencing
• Stem Cell Maintenance
• Immune Response
• Neurogenesis
• Histone Modification
• Golgi Disassembly

PTMs

• Sumoylation
• Acetylation
• Phosphorylation
• Ribosylation

• Deacetylation
• Methylation
• Demethylation
• Ubiquitination

Research Areas

• Cell Cycle and Replication
• Wnt Signaling Pathway

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CTBP2

Best Uses Of The CTBP2 Marker

The versatile CTBP2 marker can be used for biological staining. It is available in a variety of sizes and uses, and it works with 0.5 1 ml to 1.0 milliliter volumes of aqueous solution. Multichannel pipettes are ideal for larger quantities. The CTBP2 Marker provides product credits that you can use when you share your results with others. For more information check out the following article!

Benefits of using the CTBP2 Marker

The CTBP2 Marker is a promising candidate for the diagnosis and prognosis of various cancers. This protein is a transcriptional inhibitor of the tumor suppressor genes, which can lead to increased expansion and migration. After liver resection, it may be a determinant of prognosis for HCC patients. This protein is believed to play a part in various aspects of the initiation of cancer, its progression and the response to treatment. It is bound to the C-terminal region of the Adenovirus type 2/5 E1A proteins, which is involved in tumorigenesis as well as the extent of transformation into cancer.

Available

In addition to offering high-affinity primary antibodies, Boster Bio also offers an array of reagents for DNA manipulation. In the last 25 years, Boster's antibodies have been extensively cited in scientific literature and are highly regarded by researchers. These antibodies are validated on Western Blotting, Immunohistochemistry, and ELISA. They are used in both basic research as well as applied research.

The progression of liver cancer and HCC has been linked to the CTBP2 gene. Additionally, its expression correlates with the prognosis of patients following liver resection. The CTBP2 marker's availability in Boster Bio is expected to assist in the development of treatments for this disease. Boster Bio offers a wide range of reagents, tests and kits that target the CTBP2 gene.

The expression of E-cadherin , N-cadherin, Vimentin and Fibronectin decreases when siRNA is used for CtBP2 gene silencing. Silencing CtBP2 did not affect the expression of SNAI1 or Fibronectin. CtBP2 knockdown also did not affect the expression of SNAI1 and Fibronectin in Huh7 vector cells.

Cost

A CTBP2 marker has been created by combining a segment of the chicken gene DR428102 with primers that extend from the 5' end of the EST to the 3' leading edge of the CTBP2 isoform. The resulting sequence fragment was mapped to chromosome 6 of the chicken 6, and aligned using BLAT alignment with human and mouse RIBEYE excons.

Studies in molecular biology have revealed that CTBP2 has a low molecular mass band. The antibody detects the CTBP2 isoform, which is shorter. The larger CTBP2 isoform RIBEYE is also recognized. The zebrafish sequence has been found to be part of a group with other species of birds and mammals in phylogenetic analyses. It is, therefore, possible to use the CTBP2 marker to analyze the evolution of this protein.

The CTBP2 marker functions as an activator of transcription in variety of cell types, including those in your retina and ear. It may interact with SOX6, a transcription factor that influences the fate of cells in the inner ear, and also binds to a variety of transcription factors and histone desacetylases. CTBP2 connects to SOX6 and activates HDAC1. This could shed some insight into its function within the eye.

The CTBP2 gene is present in the RGCs in mice and chicks, but not in the retinas of Zebrafish. Human retinas also express CTBP2 and RIBEYE but they are not closely related. RIBEYE and CTBP2 are evolutionary conserved between humans and chicks. They come from the same source as mouse and mouse.