CXCR5 Infographic
C-X-C chemokine receptor type 5 Info At a glance, species: Human
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C-X-C chemokine receptor type 5 (CXCR5)
Cytokine receptor which binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration to B-cell follicles of spleen and Peyer patches but not to those of mesenteric or peripheral lymph nodes.
May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis or B-cell differentiation. .
Gene Information
| Human | |
|---|---|
| Gene Name: | CXCR5 |
| Uniprot: | P32302 |
| Entrez: | 643 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 1 family |
Alternative Names
BLR1; BLR1MDR-15; Burkitt lymphoma receptor 1; Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif)receptor 5); Burkitt lymphoma receptor 1, GTP-binding protein; CD185 antigen; CD185; chemokine (C-X-C motif) receptor 5; C-X-C chemokine receptor type 5; CXCR5; CXC-R5; MDR15CXCR-5; MGC117347; Monocyte-derived receptor 15
Molecular Weight
Mass (kDA):
41.955 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q23.3 |
| Sequence: | 11; NC_000011.10 (118883892..118897787) |
Tissue Specificity
Expression in mature B-cells and Burkitt lymphoma cells.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein.
Diseases
- Lymphoma
- Inflammation
- Neoplasms
- Autoimmune Reaction
- Autoimmune Diseases
- Tissue Adhesions
- Malignant Neoplasms
- Leukemia
- Neoplasm Metastasis
- Arthritis
- Malignant Paraganglionic Neoplasm
- Rheumatoid Arthritis
- B-cell Lymphomas
Interacting Proteins
- CXCR4
- GNA13
- GNAI2
- GNB3
- GNG8
Pathways
- Chemotaxis
- Pathogenesis
- Cell Differentiation
- Immune Response
- Localization
- Cell Migration
- Cell Proliferation
- Cell Development
- Cell Activation
- Secretion
- Germinal Center Formation
- Cell Cycle
- B Cell Differentiation
PTMs
- Phosphorylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CXCR5
bosterbio.com/bosterbio-gene-info-cards/CXCR5
References
PMID: 1425907 by Dobner T., et al. Differentiation-specific expression of a novel G protein-coupled receptor from Burkitt's lymphoma.
PMID: 7639692 by Barella L., et al. Sequence variation of a novel heptahelical leucocyte receptor through alternative transcript formation.
