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- Table of Contents
Cytochrome P450 2C9 Antibodies
AND CYP2C9 ELISA kits, Cytochrome P450 2C9 Proteins
Many biological assays use antibodies to detect Cytochrome P450 2C9, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Cytochrome P450 2C9 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Cytochrome P450 2C9 antibodies...
Designing a Western blot for Cytochrome P450 2C9? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the CYP2C9 Western Blot GuideCYP2C9 Infographic by Boster Bio
All CYP2C9 Products
Product
Figures
Specificity
Applications
Price
Human
$960
Cat # LS001559
20 µg, 100 µg
Cat # LS001559
20 µg, 100 µg
Human
Flow Cytometry, IF, ICC, WB
$370
Cat # M00465-1
100 μl/vial
Cat # M00465-1
100 μl/vial
CYP2C9 Overview
Facts about Cytochrome P450 2C9.
Cytochrome P450 2C9 (CYP2C9)
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway.
It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics (PubMed:25994031). This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan (PubMed:25994031).
Gene Information
| Human | |
|---|---|
| Gene Name: | CYP2C9 |
| Uniprot: | P11712 |
| Entrez: | 1559 |
Family
| Belongs to: |
|---|
| cytochrome P450 family |
Alternative Names
(R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CPC9; CYP2C; CYP2C10; CYPIIC9; cytochrome P450 2C9; Cytochrome P450 MP-4; Cytochrome P450 MP-8; Cytochrome P450 PB-1; cytochrome P-450 S-mephenytoin 4-hydroxylase; cytochrome P450, family 2, subfamily C, polypeptide 9; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 9; Cytochrome P-450MP; EC 1.14.13.48; EC 1.14.13.49; EC 1.14.13.80; EC 1.14.14.1; flavoprotein-linked monooxygenase; MGC149605; MGC88320; microsomal monooxygenase; P450IIC9; S-mephenytoin 4-hydroxylase; xenobiotic monoo
Molecular Weight
Mass (kDA):
55.628 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10q23.33 |
| Sequence: | 10; NC_000010.11 (94938658..94990091) |
Subcellular Localizations
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Diseases
- Hemorrhage
- Malignant Neoplasms
- Medication Reaction
- Neoplasms
- Thromboembolism
- Thrombosis
- Diabetes Mellitus
- Epilepsy
- Malignant Neoplasm Of Breast
- Atrial Fibrillation
- Cardiovascular Diseases
- Hiv Infections
- Hypertensive Disease
Pathways
- Excretion
- Transport
- Demethylation
- Conjugation
- Platelet Aggregation
- Translation
- Pathogenesis
- Secretion
- Coagulation
- Hypersensitivity
- Cell Proliferation
- Glomerular Filtration
- Angiogenesis
PTMs
- Hydroxylation
- Oxidation
- Demethylation
- Carboxylation
- Acetylation
- Reduction
- Cleavage
- Sulphation
Research Areas
- Lipid and Metabolism
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CYP2C9
bosterbio.com/bosterbio-gene-info-cards/CYP2C9
References
PMID: 2827463 by Meehan R.R., et al. Human cytochrome P-450 PB-1: a multigene family involved in mephenytoin and steroid oxidations that maps to chromosome 10.
PMID: 3697070 by Kimura S., et al. cDNA and amino acid sequences of two members of the human P450IIC gene subfamily.