Epithelial discoidin domain-containing receptor 1 (DDR1)

Tyrosine kinase that acts as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell regeneration. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases.

Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal ear morphology and normal hearing (By similarity).